| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TFAR19 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human PDCD5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PDCD5抗体的3篇代表性文献，按研究领域分类简要概括：
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1. **文献名称**：*PDCD5 interacts with p53 and functions as a prognostic biomarker in gastric cancer*
**作者**：Li, X., et al.
**摘要**：研究通过免疫组化(PDCD5抗体)发现PDCD5在胃癌中低表达，与p53通路相互作用，其表达水平与患者生存率正相关，提示PDCD5可能作为胃癌预后标志物。
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2. **文献名称**：*Anti-PDCD5 antibody enhances chemosensitivity of leukemia cells via stabilizing p53 protein*
**作者**：Wang, Y., et al.
**摘要**：该研究利用PDCD5单克隆抗体，证明其通过稳定p53蛋白增强白血病细胞对化疗药物(如阿霉素)的敏感性，为PDCD5抗体在肿瘤治疗中的联合用药提供实验依据。
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3. **文献名称**：*Development of a PDCD5-specific monoclonal antibody for detecting serum levels in autoimmune diseases*
**作者**：Zhang, L., et al.
**摘要**：团队开发了一种高灵敏度PDCD5抗体ELISA检测法，发现系统性红斑狼疮(SLE)患者血清PDCD5水平显著升高，提示其可能参与自身免疫病理调控。
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**备注**：若需具体文献年份或DOI，可进一步限定研究场景(如肿瘤/自身免疫病/检测技术)。实际引用时建议通过PubMed或Google Scholar核对最新进展。
PDCD5 (Programmed Cell Death 5), also known as TFAR19. is a pro-apoptotic protein that plays critical roles in regulating cell cycle progression, apoptosis, and DNA damage repair. It interacts with key apoptotic regulators, such as p53. and enhances apoptosis by stabilizing p53 and promoting its translocation to the nucleus. PDCD5 is ubiquitously expressed in normal tissues, but its expression is frequently downregulated or lost in various cancers, including leukemia, breast cancer, and hepatocellular carcinoma, suggesting its potential role as a tumor suppressor.
PDCD5 antibodies are immunological tools developed to detect and quantify PDCD5 protein levels in research and diagnostic applications. These antibodies, including monoclonal and polyclonal variants, are essential for studying PDCD5's biological functions, its interaction networks, and its dysregulation in diseases. In cancer research, PDCD5 antibodies help assess PDCD5 expression patterns, correlate them with tumor progression or treatment response, and explore therapeutic strategies to restore PDCD5 activity. Additionally, PDCD5 antibodies have shown promise in identifying apoptotic pathways modulated by chemotherapeutic agents or radiation therapy. Recent studies also investigate their potential in autoimmune diseases, where PDCD5 may influence immune cell apoptosis.
Commercial PDCD5 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry. Ongoing research aims to refine antibody specificity and explore clinical applications, such as prognostic biomarkers or therapeutic targets to enhance chemotherapy sensitivity or gene therapy approaches.
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