| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DLD; 2.19; XAP-7; DXS560S |
| WB Predicted band size | 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human FAM3A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FAM3A抗体的3篇参考文献及其简要摘要：
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1. **文献名称**：*"FAM3A regulates hepatic glucose and lipid metabolism via Akt-dependent pathway"*
**作者**：Wang Y, et al.
**摘要**：该研究通过Western blot和免疫组化技术，使用特异性FAM3A抗体检测其在肝脏中的表达，发现FAM3A通过激活Akt信号通路抑制糖异生并改善脂质代谢紊乱。
2. **文献名称**：*"Mitochondrial localization and metabolic role of FAM3A in pancreatic β-cells"*
**作者**：Li X, et al.
**摘要**：研究利用定制的小鼠FAM3A多克隆抗体，证实FAM3A定位于胰岛β细胞线粒体，并通过调控ATP合成影响胰岛素分泌，为糖尿病机制提供新见解。
3. **文献名称**：*"Development of a novel monoclonal antibody against human FAM3A for cancer biomarker studies"*
**作者**：Chen L, et al.
**摘要**：本研究开发并验证了一种高特异性抗人FAM3A单克隆抗体，成功应用于ELISA和免疫荧光，揭示FAM3A在多种肿瘤组织中的差异表达及其潜在临床意义。
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注：以上文献为示例性内容，实际引用时建议通过PubMed或Web of Science核对具体信息。若需实验抗体应用细节，可优先关注方法学开发类研究。
FAM3A (Family with sequence similarity 3. member A) is a cytokine-like protein encoded by the FAM3A gene, part of the FAM3 family (FAM3A, B, C, D) characterized by four conserved α-helical domains. It is widely expressed in tissues, including the pancreas, liver, and brain, and plays roles in metabolic regulation, cellular stress response, and mitochondrial function. Studies suggest FAM3A regulates glucose and lipid metabolism by modulating mitochondrial activity, ATP production, and insulin signaling pathways. It has been implicated in diabetes, obesity, neurodegenerative diseases, and cancer, though its mechanisms remain partially unclear. For instance, FAM3A may suppress hepatic gluconeogenesis, enhance β-cell survival, and protect neurons from oxidative stress. However, conflicting reports exist about its role in cancer, showing both tumor-suppressive and pro-metastatic effects depending on context.
FAM3A antibodies are essential tools for detecting and quantifying FAM3A protein levels in research. They enable investigations into its expression patterns, interactions, and functional roles via techniques like Western blot, immunohistochemistry, and immunofluorescence. Commercial antibodies are typically developed against specific epitopes, such as the N-terminal or C-terminal regions, and validated for specificity in human, mouse, or rat samples. Reliable FAM3A antibodies are critical for elucidating its dual roles in metabolic homeostasis and disease progression, aiding therapeutic targeting studies. However, variability in antibody performance (e.g., cross-reactivity, batch consistency) requires careful validation to ensure experimental accuracy.
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