关键信息
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基因名
BMP-15
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简介
Bone morphogenetic protein 15 (BMP-15; GDF9B), also known as growth differentiation factor 9B (GDF9B), is a polymorphic ligand protein of the TGFβ family and is only expressed in follicular cells. BMP15 is closely related to GDF9 and synergistically regulates the genetic development of follicles. BMP15 is involved in p38 MAPK and HIF-1α/SCF signaling pathway, respectively, and can up-regulate the expression of anti-Mullerian hormone (AMH) and polycystic ovarian syndrome (PCOS) related stem cell factor (SCF) in granulosa cells.
- 应用
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别名
Growth/differentiation factor 9B
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种属
Human
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表达系统
E. coli
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标签
N-His;C-Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95972
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表达区间
Q268-R392
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蛋白长度
Full Length of Mature Protein
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分子量
23.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
BMP-15 (Bone Morphogenetic Protein 15) is a member of the transforming growth factor-beta (TGF-β) superfamily, primarily expressed in the ovaries and known for its crucial role in female reproduction, particularly in oocyte development and folliculogenesis. Research has shown that BMP-15 plays a significant role in regulating ovarian function and fertility, influencing granulosa cell proliferation and differentiation. Mutations in the BMP-15 gene have been associated with various reproductive disorders, making it a focal point of study for understanding infertility and genetic factors affecting reproductive health. Additionally, BMP-15 has garnered attention in the field of biotechnology and reproductive medicine, as its recombinant protein can potentially be used for clinical applications in ovarian stimulation protocols, enhancing fertility treatments. Advances in recombinant DNA technology have allowed for the production of BMP-15 in vitro, facilitating further exploration of its biological functions and therapeutic potential. Ongoing research aims to elucidate the signaling pathways involved in BMP-15 action, its interactions with other reproductive hormones, and its potential implications in assisted reproductive technologies (ART). By comprehensively understanding BMP-15’s mechanisms, scientists hope to develop novel strategies to improve fertility outcomes and treat reproductive disorders in women.
