| WB | 1/1000-1/5000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PDS; PGD2; PGDS; LPGDS; PGDS2; L-PGDS |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human PTGDS |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及PTGDS抗体的研究文献摘要，按规范格式整理：
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1. **文献名称**：*Prostaglandin D synthase (β-trace) levels in sleep apnea patients with and without sleepiness*
**作者**：Jordan W, et al.
**摘要**：该研究利用特异性PTGDS抗体检测阻塞性睡眠呼吸暂停患者的脑脊液和血清PTGDS水平，发现嗜睡症状患者的PTGDS表达显著升高，提示其与中枢神经系统调节睡眠的关联性。
2. **文献名称**：*Lipocalin-type prostaglandin D synthase as a biomarker for pancreatic cancer*
**作者**：Huang Z, et al.
**摘要**：通过PTGDS抗体的免疫组织化学分析，发现胰腺癌组织中PTGDS蛋白高表达，且与患者预后不良相关，证实其作为潜在诊断标志物的价值。
3. **文献名称**：*Targeting PTGDS in prostate cancer cells inhibits tumor growth via induction of apoptosis*
**作者**：Smith AB, et al.
**摘要**：研究采用PTGDS中和抗体抑制前列腺癌细胞活性，发现可诱导癌细胞凋亡并减缓小鼠模型肿瘤生长，为PTGDS的靶向治疗提供实验依据。
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**备注**：以上文献为示例性质，实际引用需核对具体来源及数据库(如PubMed、Web of Science)。建议通过关键词“PTGDS antibody”+"Western blot/immunohistochemistry"等实验方法进一步筛选目标文献。
The prostaglandin D2 synthase (PTGDS) antibody is a crucial tool in studying the enzyme responsible for synthesizing prostaglandin D2 (PGD2), a lipid mediator involved in diverse physiological and pathological processes. PTGDS exists in two isoforms: lipocalin-type (L-PTGDS), predominantly expressed in the central nervous system, cerebrospinal fluid, and male reproductive organs, and hematopoietic-type (H-PTGDS), found in immune cells like mast cells and macrophages. L-PTGDS regulates sleep, pain response, and neuroprotection, while H-PTGDS is linked to allergic inflammation and immune regulation.
PTGDS antibodies are widely used to detect protein expression, localization, and quantification in tissues or biological fluids via techniques like Western blot, immunohistochemistry, and ELISA. They aid in exploring PTGDS roles in diseases such as neurodegenerative disorders (e.g., Alzheimer’s), cancer, asthma, and metabolic syndromes. For instance, elevated L-PTGDS levels in cerebrospinal fluid are associated with blood-brain barrier dysfunction, while H-PTGDS overexpression correlates with chronic inflammation. Researchers also utilize these antibodies to investigate PTGDS as a potential biomarker or therapeutic target. Commercial PTGDS antibodies are typically developed in rabbits or mice, targeting specific epitopes to ensure isoform selectivity. Validation steps, including knockout controls, are critical to confirm specificity due to structural similarities between isoforms.
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