| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | P0; LP0; L10E; RPP0; PRLP0 |
| WB Predicted band size | 34 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human RPLP0 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RPLP0抗体的参考文献示例(注：以下内容为模拟虚构，仅供参考格式)：
1. **文献名称**：*RPLP0 as a novel autoantigen in systemic lupus erythematosus*
**作者**：Peral B, et al.
**摘要**：研究通过免疫印迹法检测系统性红斑狼疮(SLE)患者血清中的抗RPLP0抗体，发现其与疾病活动性相关，提示RPLP0可能参与自身免疫反应的病理机制。
2. **文献名称**：*RPLP0 antibody as a housekeeping gene validation tool in cancer studies*
**作者**：Smith J, et al.
**摘要**：该文献评估RPLP0抗体在乳腺癌组织中的稳定性，证明其作为内参蛋白的可靠性，并对比了其在不同肿瘤亚型中的表达一致性。
3. **文献名称**：*Anti-RPLP0 antibodies in chronic lymphocytic leukemia: Prognostic implications*
**作者**：Alavian-Ghavanini A, et al.
**摘要**：研究发现慢性淋巴细胞白血病(CLL)患者中抗RPLP0抗体的高表达与不良预后相关，提示其可作为潜在生物标志物。
4. **文献名称**：*RPLP0 interacts with viral proteins and modulates host immune response*
**作者**：Chen L, et al.
**摘要**：利用RPLP0抗体进行免疫共沉淀实验，揭示RPLP0与流感病毒蛋白的相互作用，可能影响宿主抗病毒信号通路。
(提示：实际文献需通过PubMed、Google Scholar等平台检索关键词“RPLP0 antibody”或“anti-RPLP0”获取。)
The ribosomal protein lateral stalk subunit P0 (RPLP0), also known as acidic ribosomal phosphoprotein P0 or 36B4. is a key component of the 60S ribosomal subunit. It plays a structural and functional role in translation by forming the ribosomal "stalk" structure, which facilitates GTPase-dependent interactions during protein synthesis. RPLP0 is highly conserved across eukaryotes and is constitutively expressed in most tissues, making it a common reference ("housekeeping") gene in gene expression studies.
Antibodies targeting RPLP0 are widely used in research to study ribosome biogenesis, translational regulation, and cellular stress responses. They serve as critical tools for Western blotting, immunofluorescence, and immunohistochemistry to validate protein loading controls or investigate ribosomal dysfunction in diseases like cancer, neurodegenerative disorders, and ribosomopathies. However, its role as a loading control has been debated due to variable expression under certain conditions, such as cellular differentiation or drug treatment. Recent studies also implicate RPLP0 in extraribosomal functions, including cell cycle regulation and apoptosis. Commercial RPLP0 antibodies are typically validated against conserved epitopes, though species-specific cross-reactivity should be confirmed experimentally.
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