Rabbit Polyclonal RETN Antibody

The RETN gene encodes resistin, a cysteine-rich adipokine initially linked to insulin resistance and metabolic disorders in mice. In humans, resistin (also known as adipose tissue-specific secretory factor, ADSF or SEER-epsilon) is primarily secreted by macrophages and adipose tissue, playing roles in inflammation, glucose metabolism, and cardiovascular disease pathogenesis. Its expression is associated with obesity, type 2 diabetes, atherosclerosis, and autoimmune conditions. RETN antibodies are essential tools for detecting resistin levels in biological samples (serum, tissues, cell cultures) to study its physiological/pathological roles. These antibodies – polyclonal or monoclonal – enable techniques like Western blotting, ELISA, and immunohistochemistry. Species specificity is critical, as murine and human resistin share only ~55% amino acid sequence homology. Validated RETN antibodies help elucidate resistin's signaling pathways, including its interaction with Toll-like receptor 4 (TLR4) and AMP-activated protein kinase (AMPK). Recent research explores resistin's dual role as a metabolic regulator and inflammatory mediator, with therapeutic implications for metabolic syndrome and chronic inflammatory diseases. Antibody validation remains crucial due to potential cross-reactivity with other cysteine-rich proteins.