| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SCR3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human RBMS2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RBMS2抗体的3篇参考文献示例(注：文献为虚构示例，实际引用请核实真实来源)：
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1. **文献名称**：*RBMS2 Suppresses Tumor Metastasis by Stabilizing c-Myc mRNA in Colorectal Cancer*
**作者**：Wang, Y. et al. (2021)
**摘要**：本研究通过Western blot和免疫组化(使用RBMS2特异性抗体)发现，RBMS2通过结合c-Myc mRNA的3'UTR抑制其降解，从而降低c-Myc蛋白水平，阻碍结直肠癌的转移。高表达RBMS2的患者预后显著改善。
2. **文献名称**：*Prognostic Significance of RBMS2 Expression in Triple-Negative Breast Cancer*
**作者**：Liu, X. et al. (2019)
**摘要**：利用RBMS2抗体对乳腺癌组织进行免疫组化分析，发现RBMS2在三阴性乳腺癌中表达显著下调，且低表达与淋巴结转移和总生存期缩短相关，提示其可作为预后生物标志物。
3. **文献名称**：*RBMS2 Modulates let-7 Biogenesis via Interaction with LIN28A in Lung Adenocarcinoma*
**作者**：Chen, T. et al. (2020)
**摘要**：通过RNA免疫沉淀(RIP)和Co-IP实验(使用RBMS2抗体)，揭示了RBMS2与LIN28A协同调控let-7 microRNA的成熟，抑制肺癌细胞增殖和侵袭的分子机制。
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**备注**：实际研究中，RBMS2抗体多用于检测蛋白表达(如Western blot、免疫组化)或互作研究(如免疫共沉淀)。建议通过PubMed或Google Scholar以“RBMS2 antibody” + “Western blot/IHC”等关键词检索真实文献。
The RBMS2 antibody is a tool used to detect and study the RNA-binding motif single-stranded interacting protein 2 (RBMS2), a member of the RBMS family of nucleic acid-binding proteins. RBMS2 plays a critical role in post-transcriptional gene regulation by binding to RNA or single-stranded DNA, influencing processes such as RNA splicing, stability, and translation. It is implicated in various cellular functions, including cell proliferation, differentiation, and apoptosis. Dysregulation of RBMS2 has been linked to cancer progression, particularly in tumors like hepatocellular carcinoma, breast cancer, and colorectal cancer, where it may act as a tumor suppressor or oncogene depending on context.
The RBMS2 antibody is widely used in research applications, including Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), to assess protein expression levels and localization in tissues or cell lines. Its development typically involves immunizing hosts with purified RBMS2 protein fragments or synthetic peptides to generate polyclonal or monoclonal antibodies. Validation steps ensure specificity and reliability, often including knockout cell controls. Studying RBMS2 with this antibody provides insights into its molecular mechanisms, disease associations, and potential therapeutic targets. Researchers also explore its interactions with other proteins or RNA molecules to unravel its role in gene regulatory networks.
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