| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GBF1; GBF-1; PGES2; C9orf15; mPGES-2 |
| WB Predicted band size | 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human PTGES2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于PTGES2抗体的参考文献示例(内容为模拟生成)：
1. **"PTGES2 Expression and Regulation in Human Macrophages"**
- **作者**: Yamada T. et al.
- **摘要**: 利用PTGES2特异性抗体通过Western blot和免疫荧光技术，揭示了PTGES2在炎症条件下巨噬细胞中的表达上调，并证实其受NF-κB信号通路调控。
2. **"Differential Roles of PTGES Isoforms in Colorectal Cancer"**
- **作者**: Smith J.R., Chen L.
- **摘要**: 通过免疫组化分析PTGES2抗体在结直肠癌组织中的定位，发现PTGES2高表达与患者生存率负相关，且其功能区别于PTGES1/PTGES3.
3. **"Subcellular Localization of PTGES2 in Mitochondria"**
- **作者**: Müller S. et al.
- **摘要**: 使用PTGES2抗体进行细胞分馏实验，首次证明PTGES2定位于线粒体，并参与氧化应激相关的前列腺素合成。
4. **"PTGES2 in Neurodegenerative Diseases: A Biomarker Study"**
- **作者**: Johnson K., Patel R.
- **摘要**: 通过ELISA和免疫印迹检测脑脊液中PTGES2水平，提示其可能作为阿尔茨海默病的潜在炎症标志物。
(注：以上文献为虚构示例，实际研究需通过PubMed/Google Scholar等平台检索。)
The PTGES2 (Prostaglandin E Synthase 2) antibody is a tool used to detect and study the PTGES2 protein, a membrane-associated enzyme involved in prostaglandin E2 (PGE2) synthesis. PTGES2 catalyzes the conversion of prostaglandin H2 (PGH2) to PGE2. a lipid mediator critical in inflammation, pain, fever, and cellular homeostasis. Unlike other prostaglandin synthases, PTGES2 is constitutively expressed and may function independently of cyclooxygenase-2 (COX-2), suggesting roles in both physiological and pathological processes. Research highlights its potential involvement in cancer progression, neurodegenerative diseases, and cardiovascular conditions.
The antibody is primarily used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to analyze PTGES2 expression, localization, and regulation across tissues. Validated antibodies help clarify PTGES2’s tissue-specific expression patterns, interactions with other signaling molecules, and its role in diseases. For instance, elevated PTGES2 levels in certain tumors correlate with poor prognosis, implicating it in tumor growth or metastasis. Studies also explore its neuroprotective or detrimental effects in Alzheimer’s disease.
As PTGES2 gains attention as a therapeutic target, its antibody serves as a biomarker-discovery tool and aids in evaluating drug efficacy targeting the PGE2 pathway. Specificity validation (e.g., knockout controls) ensures reliable results, minimizing cross-reactivity with homologous enzymes like PTGES1 or PTGES3.
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