| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
以下是关于SOX7抗体的3篇参考文献示例(文献信息为模拟概括，仅供参考)：
1. **"SOX7 functions as a tumor suppressor in colorectal cancer by repressing Wnt/β-catenin signaling"**
- **作者**: Zhang Y, et al.
- **摘要**: 本研究利用SOX7特异性抗体进行免疫组化和Western blot分析，发现SOX7在结直肠癌组织中表达下调，并通过抑制Wnt通路活性抑制肿瘤生长，提示其作为潜在治疗靶点。
2. **"Sox7 regulates the expression of VE-cadherin in endothelial cells during vascular development"**
- **作者**: Kim I, et al.
- **摘要**: 通过SOX7抗体的免疫荧光染色，作者发现Sox7在小鼠胚胎血管内皮细胞中调控VE-cadherin表达，影响血管形成，强调了Sox7在胚胎发育中的关键作用。
3. **"Loss of SOX7 expression correlates with poor prognosis in hepatocellular carcinoma"**
- **作者**: Wang L, et al.
- **摘要**: 使用SOX7抗体对肝癌组织进行检测，发现SOX7低表达与患者生存率下降显著相关，其缺失可能通过促进上皮-间质转化(EMT)驱动肝癌进展。
**备注**：以上为示例性内容，实际文献需通过PubMed、Web of Science或Google Scholar等平台以“SOX7 antibody”及“SOX7 function”等关键词检索获取。
**Background of SOX7 Antibody**
SOX7. a member of the SOX (Sry-related HMG box) family of transcription factors, plays critical roles in embryonic development, cell differentiation, and tissue homeostasis. It binds to DNA through its conserved HMG domain, regulating target genes involved in organogenesis, cardiovascular development, and stem cell maintenance. SOX7 is also implicated in cancer biology, where it often acts as a tumor suppressor by inhibiting Wnt/β-catenin signaling and suppressing epithelial-mesenchymal transition (EMT).
SOX7 antibodies are essential tools for studying the expression, localization, and function of the SOX7 protein in various biological contexts. These antibodies are widely used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to detect SOX7 in tissue sections, cell lines, or experimental models. Given the high homology among SOX family members, SOX7 antibodies must exhibit high specificity to avoid cross-reactivity with related proteins like SOX17 or SOX18. Validation often includes knockout controls or siRNA-mediated knockdown to confirm target specificity.
Research utilizing SOX7 antibodies has expanded insights into developmental disorders, cancer progression, and regenerative mechanisms. Dysregulation of SOX7 is linked to conditions such as colorectal cancer, lung adenocarcinoma, and congenital heart defects, underscoring its clinical relevance. Reliable SOX7 antibodies thus serve as vital reagents for both basic research and translational studies.
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