| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | SNAPA |
| WB Predicted band size | 33 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human NAPA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NAPA(α-SNAP)抗体的参考文献示例(注：文献为假设性示例，实际文献需通过学术数据库检索确认)：
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1. **文献名称**: "Role of α-SNAP in Regulating Neurotransmitter Release"
**作者**: Martin, T.F., et al.
**摘要**: 研究α-SNAP蛋白在突触囊泡融合中的作用，利用特异性抗体验证其在神经分泌中的功能，揭示其与SNARE复合物的相互作用机制。
2. **文献名称**: "Altered Expression of α-SNAP in Diabetic Mouse Models"
**作者**: Sugawara, K., et al.
**摘要**: 通过免疫组化和Western blot分析，发现糖尿病模型中α-SNAP表达水平下降，提示其可能与胰岛素分泌异常相关。
3. **文献名称**: "Development of a High-Affinity Monoclonal Antibody for α-SNAP Detection"
**作者**: Hsu, S.C., et al.
**摘要**: 描述一种新型抗α-SNAP单克隆抗体的制备方法，验证其在细胞成像和蛋白质相互作用研究中的高特异性和灵敏度。
4. **文献名称**: "α-SNAP Dysfunction in Immune Cell Vesicle Trafficking"
**作者**: Brown, A.M., et al.
**摘要**: 探究α-SNAP抗体在巨噬细胞吞噬作用研究中的应用，揭示其在免疫细胞囊泡运输中的关键调控作用。
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**注意**：以上文献为示例性质，实际研究中请通过PubMed、Google Scholar等平台检索关键词(如"α-SNAP antibody"、"NAPA protein")获取最新研究成果。
NAPA (NSF Attachment Protein Alpha), also known as α-SNAP, is a critical component of intracellular vesicle trafficking and membrane fusion processes. It belongs to the SNAP family of soluble proteins that interact with the SNARE (Soluble NSF Attachment Protein Receptor) complex, which mediates the fusion of transport vesicles with target membranes. NAPA binds to the SNARE complex and recruits NSF (N-ethylmaleimide-sensitive fusion protein), an ATPase essential for disassembling SNAREs after fusion, thereby recycling them for subsequent rounds of membrane docking. This mechanism is vital for neurotransmitter release, organelle biogenesis, and protein secretion.
Antibodies targeting NAPA are widely used in biomedical research to study vesicular transport dynamics, synaptic function, and cellular secretion pathways. They enable the detection, localization, and quantification of NAPA in various experimental models, including immunoprecipitation, Western blotting, and immunofluorescence microscopy. Dysregulation of NAPA has been implicated in neurological disorders, such as epilepsy and neurodegenerative diseases, as well as in cancer progression due to its role in regulating cell proliferation and apoptosis. Research utilizing NAPA antibodies has provided insights into pathological mechanisms and potential therapeutic targets. These antibodies thus serve as essential tools for elucidating the molecular basis of vesicle trafficking and its implications in health and disease.
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