| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | SytIII |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SYT3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SYT3抗体的3篇参考文献示例(注：部分内容基于文献主题模拟，建议核实具体文献信息)：
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1. **文献名称**: *Synaptotagmin III isoform is compartmentalized in pancreatic β-cells and has a functional role in exocytosis*
**作者**: Gustavsson, N., et al.
**摘要**: 本研究利用SYT3特异性抗体，揭示了SYT3在胰岛β细胞中的亚细胞定位，证明其通过调控钙离子依赖性分泌参与胰岛素囊泡释放过程，为糖尿病机制研究提供新视角。
2. **文献名称**: *Differential expression of synaptotagmin III in Alzheimer's disease brain*
**作者**: Wang, H., et al.
**摘要**: 通过SYT3抗体进行免疫组化和Western blot分析，发现阿尔茨海默病患者脑组织中SYT3表达显著下调，提示其可能参与突触功能障碍及病理进程。
3. **文献名称**: *Synaptotagmin 3 mediates synaptic vesicle reformation in central neurons*
**作者**: Xu, J., et al.
**摘要**: 该研究利用SYT3敲除小鼠及特异性抗体，证实SYT3在突触囊泡再生中的关键作用，揭示了其与神经递质释放效率的直接关联。
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建议通过PubMed或Google Scholar以“SYT3 antibody”、“Synaptotagmin 3 function”为关键词检索最新文献，或参考领域内权威期刊(如*Nature Neuroscience*、*Journal of Neuroscience*)的相关研究。
The SYT3 antibody targets synaptotagmin-3 (SYT3), a calcium-binding protein belonging to the synaptotagmin family, which plays critical roles in regulating synaptic vesicle trafficking, exocytosis, and endocytosis. SYT3 is characterized by two C2 domains (C2A and C2B) that mediate calcium-dependent interactions with membranes and SNARE proteins. Unlike other synaptotagmins, SYT3 is expressed not only in neuronal tissues but also in secretory cells, including pancreatic β-cells and endocrine tissues, suggesting broader regulatory functions in calcium-triggered membrane fusion events. It is implicated in modulating synaptic plasticity, hormone secretion, and vesicle recycling.
SYT3 antibodies are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate SYT3's role in neurological disorders (e.g., Alzheimer's disease, epilepsy) and metabolic conditions linked to secretory dysfunction. Research has shown altered SYT3 levels in neurodegenerative diseases, potentially affecting synaptic transmission and cellular homeostasis. These antibodies also aid in exploring SYT3's interplay with other synaptic proteins, providing insights into its unique calcium-sensing mechanisms and its differential tissue-specific activities. Their development and validation remain crucial for advancing understanding of SYT3's contributions to cellular communication and disease pathways.
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