| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | HsT1192 |
| WB Predicted band size | 48 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SYT4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SYT4抗体的参考文献示例(注：以下文献为模拟示例，实际引用时请核实真实来源)：
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1. **文献名称**: "Synaptotagmin-IV Regulates Dopamine Release and Cognitive Flexibility in Mice"
**作者**: Zhang L, et al.
**摘要**: 研究通过SYT4抗体进行免疫印迹和免疫荧光，发现SYT4敲除小鼠的多巴胺释放减少，导致认知灵活性缺陷，提示SYT4在神经递质调控中的关键作用。
2. **文献名称**: "Synaptotagmin-4 Antibody Validation for Neuronal Subtype Localization"
**作者**: Tanaka K, et al.
**摘要**: 本文验证了SYT4抗体的特异性，证明其适用于区分海马区不同神经元亚型，并通过免疫组化揭示了SYT4在抑制性中间神经元中的高表达。
3. **文献名称**: "SYT4 Modulates Insulin Secretion via Calcium Sensing in Pancreatic β-Cells"
**作者**: Patel R, et al.
**摘要**: 利用SYT4抗体检测β细胞中SYT4的表达，发现其通过钙离子感应调控胰岛素囊泡分泌，为糖尿病机制研究提供新视角。
4. **文献名称**: "Synaptotagmin-4 Dysregulation in Alzheimer's Disease Postmortem Brains"
**作者**: Chen H, et al.
**摘要**: 通过SYT4抗体分析阿尔茨海默病患者脑组织，发现SYT4在颞叶皮层表达显著下调，可能与其突触功能障碍和病理沉积相关。
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**注意**：以上文献为示例性质，实际研究中请通过PubMed、Google Scholar等平台检索真实文献，并使用学术数据库(如Web of Science)确认详细信息。若需具体文献协助，可提供更详细的研究背景或关键词进一步筛选。
The SYT4 antibody targets Synaptotagmin-4 (SYT4), a member of the synaptotagmin family of calcium-binding proteins involved in membrane trafficking and synaptic transmission. Primarily expressed in neuronal tissues, SYT4 is localized to synaptic vesicles and secretory granules, where it regulates exocytosis and intracellular signaling. Unlike other synaptotagmins, SYT4 lacks a strong calcium-binding motif, suggesting distinct regulatory roles in neuroendocrine cells or plasticity-related processes. Studies link SYT4 to neurodevelopmental disorders, neurodegenerative diseases, and certain cancers, highlighting its diverse physiological and pathological relevance.
SYT4 antibodies are essential tools for detecting SYT4 expression and distribution in research applications such as Western blotting, immunohistochemistry, and immunofluorescence. They help elucidate SYT4’s interaction networks, subcellular localization, and functional contributions to vesicle dynamics or calcium-triggered secretion. Commercial SYT4 antibodies are typically validated for specificity across human, mouse, and rat models. However, variability in antibody performance (e.g., cross-reactivity with other synaptotagmins) necessitates careful validation for experimental accuracy. Ongoing research using SYT4 antibodies continues to uncover its role in synaptic plasticity, hormone release, and disease mechanisms, making it a critical reagent in neuroscience and cell biology.
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