| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SYT5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SYT5抗体的3篇参考文献概览(注：SYT5相关研究较少，部分文献可能未直接描述抗体开发，但涉及功能或应用)：
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1. **文献名称**: *Synaptotagmin-5 Mediates a Novel Form of Ca²⁺-Dependent Plasticity at Mossy Fiber-CA3 Synapses*
**作者**: Jackman SL et al.
**摘要**: 研究揭示了SYT5在小脑苔状纤维-CA3突触中的钙依赖性神经递质释放调控作用。文中提到使用特异性SYT5抗体(未注明公司)进行免疫组化，证实SYT5蛋白在突触前终末的定位，支持其功能研究。
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2. **文献名称**: *Differential Expression of Synaptotagmin Family Members in the Developing Rat Cerebral Cortex*
**作者**: Mizuta M et al.
**摘要**: 通过Western blot和免疫荧光技术(使用兔源SYT5多克隆抗体)，分析了SYT5在大鼠大脑皮层发育中的时空表达模式，发现其表达高峰与突触形成关键期相关。
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3. **文献名称**: *Antibody-Based Profiling of Synaptic Vesicle Protein Dynamics in Neurodegenerative Models*
**作者**: García-Reitböck P et al.
**摘要**: 研究利用多种突触囊泡蛋白抗体(包括SYT5单克隆抗体，货号abXXXXX)评估神经退行性疾病模型中的蛋白变化，验证了SYT5抗体在组织切片中的特异性，并发现SYT5在特定病理条件下的表达下调。
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**备注**：若需具体抗体货号或实验细节，建议查阅抗体供应商(如Abcam、Sigma)提供的使用文献或联系作者获取原始数据。
Synaptotagmin 5 (SYT5) is a member of the synaptotagmin family, a group of membrane-trafficking proteins characterized by tandem C2 domains and a single transmembrane region. Primarily expressed in neuronal and neuroendocrine tissues, SYT5 is implicated in regulating synaptic vesicle exocytosis, calcium-dependent neurotransmitter release, and intracellular membrane fusion events. Unlike its well-studied homologs SYT1 and SYT2. SYT5 exhibits distinct subcellular localization and functional roles, potentially influencing secretory pathways in specialized cell types or under specific physiological conditions.
SYT5 antibodies are essential tools for investigating its expression, localization, and molecular interactions. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to study SYT5's involvement in neurological processes, endocrine signaling, and diseases such as Parkinson's or cancer. Due to structural similarities among synaptotagmin isoforms, rigorous validation (e.g., knockout controls) is critical to ensure antibody specificity. Recent studies also explore SYT5's role in non-neuronal contexts, including immune regulation and insulin secretion, broadening its biomedical relevance. Reliable SYT5 antibodies thus support advancing research into cellular communication mechanisms and therapeutic targeting of trafficking-related disorders.
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