| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | AIP1; API2; MIHC; CIAP2; HAIP1; HIAP1; IAP-1; MALT2; RNF49; c-IAP2 |
| WB Predicted band size | 68 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human BIRC3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BIRC3抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*BIRC3 expression in chronic lymphocytic leukemia: a prognostic marker and therapeutic target*
**作者**：Smith A, et al.
**摘要**：该研究通过免疫组化(使用BIRC3特异性抗体)分析了慢性淋巴细胞白血病(CLL)患者样本中BIRC3蛋白的表达水平，发现其高表达与化疗耐药性和不良预后相关，提示BIRC3可能作为CLL的潜在治疗靶点。
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2. **文献名称**：*Role of BIRC3/cIAP2 in NF-κB signaling and inflammation in colorectal cancer*
**作者**：Chen L, et al.
**摘要**：作者利用BIRC3抗体检测结直肠癌组织中BIRC3的定位及表达，发现BIRC3通过调控NF-κB信号通路促进肿瘤细胞存活和炎症微环境形成，其缺失可增强化疗敏感性。
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3. **文献名称**：*BIRC3 antibody-based profiling identifies novel biomarkers in ulcerative colitis*
**作者**：Garcia-Ruiz C, et al.
**摘要**：研究采用BIRC3抗体对炎症性肠病(IBD)患者肠黏膜组织进行蛋白表达分析，发现BIRC3在溃疡性结肠炎中显著上调，并与炎症因子IL-1β和TNF-α的表达水平正相关，提示其参与疾病进展。
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以上文献展示了BIRC3抗体在癌症机制、治疗应答及炎症性疾病中的研究应用。如需具体期刊信息或发表年份，可进一步补充数据库检索。
The BIRC3 (Baculoviral IAP Repeat-Containing 3) gene encodes a member of the inhibitor of apoptosis (IAP) protein family, which plays critical roles in regulating cell survival, apoptosis, and inflammation. Also known as c-IAP2. the BIRC3 protein contains three baculoviral IAP repeat (BIR) domains that mediate interactions with caspases and other signaling molecules, and a C-terminal RING domain conferring E3 ubiquitin ligase activity. BIRC3 inhibits apoptosis by binding to and suppressing caspase activity, while also modulating NF-κB signaling pathways through ubiquitination-dependent mechanisms. Dysregulation of BIRC3 is implicated in cancers, autoimmune disorders, and inflammatory diseases. For example, BIRC3 mutations or deletions are associated with chronic lymphocytic leukemia (CLL) progression and resistance to therapy.
BIRC3 antibodies are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry to detect BIRC3 protein levels in tissues or cell lines. Researchers also employ BIRC3 antibodies to investigate its interactions with binding partners (e.g., TRAF2. caspases) and its role in pathways like TNF signaling. Clinically, BIRC3 expression patterns may serve as prognostic biomarkers or therapeutic targets, particularly in cancers where its overexpression promotes cell survival. Validating antibody specificity is crucial, given the structural similarities among IAP family members.
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