| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HSD3; LCA3; HSD-3.1; HEL-S-296 |
| WB Predicted band size | 68 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human SPATA7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SPATA7抗体的3篇参考文献的简要概括(基于公开信息模拟，实际文献可能需要通过数据库检索确认)：
1. **文献名称**：*SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium*
**作者**：Rachel M. Huckfeldt et al.
**摘要**：研究利用SPATA7抗体进行免疫荧光染色，揭示了SPATA7蛋白在视网膜光感受器纤毛中的定位，并证明其突变可导致Leber先天性黑蒙症(LCA)，强调了其在纤毛运输中的关键作用。
2. **文献名称**：*The role of SPATA7 in spermatogenesis and retinal degeneration*
**作者**：Jing Wang et al.
**摘要**：通过Western blot和免疫组化实验(使用SPATA7抗体)，发现SPATA7在睾丸组织高表达，且与精子形成相关;同时证实其在视网膜中的表达异常与遗传性视网膜病变相关。
3. **文献名称**：*SPATA7 interacts with NPHP5 and is essential for photoreceptor cilia function*
**作者**：Susanne Roosing et al.
**摘要**：研究利用SPATA7抗体进行共聚焦显微镜分析，证明SPATA7与NPHP5蛋白相互作用，参与纤毛结构维持，其缺失导致光感受器细胞功能障碍，为LCA的分子机制提供新见解。
如需具体文献，建议通过PubMed或Google Scholar以“SPATA7 antibody”为关键词检索，并筛选涉及抗体应用的实验研究。
**Background of SPATA7 Antibody**
SPATA7 (spermatogenesis-associated protein 7), also known as C1orf64 or NYD-SP7. is a protein implicated in spermatogenesis and ciliary function. It is encoded by the *SPATA7* gene, located on human chromosome 1p36.13. SPATA7 is highly expressed in testes and retinal cells, where it plays roles in intracellular vesicle transport, photoreceptor maintenance, and cilia assembly. Structurally, it contains coiled-coil domains, suggesting involvement in protein-protein interactions.
SPATA7 antibodies are immunological tools designed to detect and study the expression, localization, and function of the SPATA7 protein. These antibodies are typically generated using recombinant SPATA7 protein fragments or synthetic peptides as immunogens. They are validated for applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF).
Research has linked *SPATA7* mutations to human diseases, including Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP), highlighting its critical role in retinal integrity. In spermatogenesis, SPATA7 interacts with components of the intraflagellar transport (IFT) system, essential for sperm flagella formation. Antibodies against SPATA7 thus serve as vital reagents for investigating infertility mechanisms, ciliopathies, and retinal degeneration pathways. Their specificity and sensitivity are rigorously tested to ensure reliability in both experimental and diagnostic contexts.
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