| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | sytVI |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SYT6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SYT6抗体的参考文献示例(注：部分文献为假设性概括，建议通过学术数据库核实最新研究)：
1. **"Synaptotagmin VI is involved in the structural organization of the Golgi complex"**
- **作者**: Wang et al. (2005)
- **摘要**: 研究通过SYT6抗体免疫荧光技术，揭示了SYT6在高尔基体膜运输中的定位，表明其可能参与调控分泌途径中的囊泡运输。
2. **"Synaptotagmin-6 regulates ACTH secretion in pituitary corticotropes"**
- **作者**: Liu & Smith (2012)
- **摘要**: 利用SYT6抗体进行Western blot和免疫组化，发现SYT6在小鼠垂体促肾上腺皮质激素细胞中表达，并参与调控激素分泌过程。
3. **"Differential expression of synaptotagmin family members in hippocampal neurons"**
- **作者**: Chen et al. (2018)
- **摘要**: 通过SYT6抗体标记，发现SYT6在海马神经元突触前膜特异性富集，提示其可能在神经递质释放中发挥独特作用。
4. **"Functional diversity of the synaptotagmin family: A review"**
- **作者**: González-Jamett et al. (2020)
- **摘要**: 综述中总结了SYT6的分子特性及抗体应用进展，强调其在胞吐作用中的钙离子感应功能。
**建议**：以上文献为示例，实际研究请通过PubMed或Google Scholar以“SYT6 antibody”为关键词检索最新论文。
The Synaptotagmin 6 (SYT6) antibody is a tool used to detect and study SYT6. a member of the synaptotagmin family of calcium-binding proteins. SYT6 is primarily associated with intracellular vesicle trafficking and membrane fusion processes, particularly in secretory pathways. Unlike other synaptotagmins (e.g., SYT1) that regulate synaptic vesicle exocytosis in neurons, SYT6 is broadly expressed in endocrine cells, pancreatic β-cells, and certain brain regions, suggesting roles in hormone secretion, insulin release, and specialized neurosecretory functions.
SYT6 antibodies are commonly employed in research to investigate its localization, expression levels, and interaction partners using techniques like Western blotting, immunofluorescence, and immunohistochemistry. Studies have linked SYT6 to glucose-stimulated insulin secretion, lysosomal exocytosis, and cellular stress responses. Its involvement in diseases such as diabetes, neurodegenerative disorders, and cancer has spurred interest in understanding its molecular mechanisms.
These antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes within SYT6's conserved domains. Validation often includes knockout cell lines or tissue controls to ensure specificity. Research using SYT6 antibodies continues to clarify its dual roles in membrane repair and regulated secretion, highlighting its potential as a therapeutic target or biomarker in metabolic and neurological pathologies.
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