关键信息
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基因名
S100P
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简介
The S100P protein is a multifunctional calcium sensor that actively contributes to cellular calcium signaling. It interacts calcium-dependently with proteins such as EZR and PPP5C, indirectly affecting processes such as microvilli formation. S100P Protein, Human (His) is the recombinant human-derived S100P protein, expressed by E. coli , with N-6*His labeled tag.
- 应用
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别名
Protein S100-P; Protein S100-E; S100 Calcium-Binding Protein P; S100P; S100E
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P25815
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表达区间
M1-K95
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蛋白长度
Full Length
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分子量
12.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
S100P is a member of the S100 protein family, characterized by its high affinity for calcium ions and involvement in various intracellular processes. Research into S100P has gained momentum due to its association with significant pathological conditions, particularly in cancer. Elevated levels of S100P have been observed in several malignancies, including breast, pancreatic, and prostate cancers, indicating its potential role as a biomarker for tumor progression and metastasis. The protein is known to interact with various cell signaling pathways and cytoskeletal proteins, influencing cell proliferation, differentiation, and apoptosis. Additionally, S100P may contribute to the tumor microenvironment, promoting invasiveness and resistance to therapy. Given these attributes, S100P is not only a target for understanding the molecular mechanisms of cancer progression but also a promising candidate for therapeutic interventions. Researchers are actively exploring the protein's structure-function relationship, signaling pathways, and potential as a prognostic marker, aiming to elucidate its role in cancer biology further and develop S100P-targeted strategies for cancer diagnosis and treatment.
