| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | p72-Syk |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SYK |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SYK抗体的3篇代表性文献摘要(人工整理示例，非真实文献)：
1. **文献名称**：*Spleen tyrosine kinase (SYK) inhibitor suppresses rheumatoid arthritis progression via modulating dendritic cell immune activation*
**作者**：Smith J, et al.
**摘要**：研究证明SYK抗体通过抑制树突状细胞中SYK介导的炎症信号通路，显著减轻小鼠类风湿性关节炎模型的关节损伤和自身免疫反应，提示其治疗潜力。
2. **文献名称**：*Targeting SYK in diffuse large B-cell lymphoma: mechanisms and therapeutic implications*
**作者**：Chen L, et al.
**摘要**：该文献发现SYK在B细胞淋巴瘤中异常激活，使用特异性SYK单克隆抗体可阻断下游BCR信号传导，诱导肿瘤细胞凋亡，为靶向治疗提供实验依据。
3. **文献名称**：*Anti-SYK nanoparticles attenuate neutrophil extracellular trap formation in systemic lupus erythematosus*
**作者**：Wang Y, et al.
**摘要**：开发了一种靶向SYK的纳米抗体，通过抑制中性粒细胞NETosis过程，显著改善狼疮小鼠模型的肾脏病理损伤和自身抗体水平。
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注：以上内容为模拟示例，实际文献需通过PubMed/Google Scholar检索关键词(如"SYK antibody"+"disease"或"SYK inhibitor")。真实研究可参考：
- SYK与免疫受体信号(如Nature Immunology)
- SYK抑制剂临床前研究(如Blood, Journal of Clinical Investigation)
**Background of SYK Antibodies**
Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase primarily expressed in hematopoietic cells, where it plays a central role in signal transduction pathways. It is activated downstream of immunoreceptors, including B-cell receptors (BCR), Fc receptors, and integrins, mediating critical processes such as immune cell activation, proliferation, and differentiation. SYK's involvement in these pathways has linked it to various immune-related disorders and cancers, particularly hematologic malignancies like leukemia and lymphoma.
SYK antibodies are tools designed to detect, quantify, or inhibit SYK protein activity in research and clinical settings. In research, they help elucidate SYK's functional roles, such as its contribution to inflammatory responses or oncogenic signaling. Clinically, SYK inhibitors (a form of therapeutic antibodies or small molecules) are explored for treating autoimmune diseases (e.g., rheumatoid arthritis) and cancers, where aberrant SYK activation drives pathogenesis. Additionally, diagnostic SYK antibodies aid in detecting SYK expression levels in tissues, serving as biomarkers for disease progression or therapeutic targeting.
The development of SYK-targeted therapies underscores its significance as a molecular target, though challenges like off-target effects and resistance mechanisms remain areas of active investigation.
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