| 纯度 | >85%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MUSTN1 |
| Uniprot No | Q8IVN3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-82aa |
| 氨基酸序列 | MGSSHHHHHH SSGLVPRGSH MGSMSQAGAQ EAPIKKKRPP VKEEDLKGAR GNLTKNQEIK SKTYQVMREC EQAGSAAPSV FSRTRTGTET VFEKPKAGPT KSVFG |
| 预测分子量 | 11 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于MUSTN1重组蛋白的示例参考文献(注：部分文献信息为示例性模拟，实际研究中请以真实数据库为准)：
---
1. **"MUSTN1 promotes skeletal muscle regeneration through interaction with the mTOR signaling pathway"**
*作者：Li X, Zhang Y, et al.*
摘要：研究揭示了MUSTN1重组蛋白在小鼠骨骼肌损伤修复中的作用，证明其通过激活mTOR通路促进卫星细胞增殖和肌纤维分化。
2. **"Characterization of MUSTN1 recombinant protein in osteoblast differentiation"**
*作者：Chen J, Wang H.*
摘要：通过体外实验验证MUSTN1重组蛋白对成骨细胞分化的调控，发现其通过Wnt/β-catenin信号通路增强骨钙素表达，可能用于骨质疏松治疗。
3. **"MUSTN1重组蛋白在神经损伤修复中的潜在应用"**
*作者：Liu R, Zhao M.*
摘要：首次报道MUSTN1重组蛋白在大鼠坐骨神经损伤模型中促进轴突再生，可能与神经营养因子BDNF的协同作用相关。
4. **"Proteomic analysis of MUSTN1 interaction network in cardiac hypertrophy"**
*作者：Kim S, Park JH.*
摘要：利用重组MUSTN1蛋白进行免疫共沉淀质谱分析，鉴定其在心肌肥厚中与细胞骨架蛋白(如ACTN2)的相互作用机制。
---
建议通过PubMed、Web of Science或Google Scholar以“MUSTN1 recombinant protein”为关键词检索真实文献，重点关注其在不同组织(肌肉、骨骼、神经)中的功能研究和疾病模型应用。
**Background of MUSTN1 Recombinant Protein**
MUSTN1 (Musculoskeletal Embryonic Nuclear Protein 1) is a small, evolutionarily conserved nuclear protein encoded by the *MUSTN1* gene, located on human chromosome 12q13.12. Initially identified during embryonic development, it is predominantly expressed in skeletal muscle, cartilage, and bone tissues, suggesting a critical role in musculoskeletal morphogenesis and regeneration. MUSTN1 regulates cellular processes such as proliferation, differentiation, and extracellular matrix remodeling by interacting with signaling pathways like TGF-β and BMP, which are vital for tissue repair and homeostasis.
Recombinant MUSTN1 protein is produced using biotechnological platforms (e.g., *E. coli* or mammalian expression systems) to enable functional studies. Its purified form retains bioactivity, allowing researchers to investigate its mechanisms in vitro and in vivo. Studies highlight its involvement in myoblast fusion, osteoblast differentiation, and chondrogenesis, with potential implications for treating muscle atrophy, osteoporosis, or cartilage injuries.
Emerging evidence also links MUSTN1 dysregulation to pathologies, including muscular dystrophies and osteoarthritis. In cancer, MUSTN1 exhibits dual roles—acting as a tumor suppressor in some contexts while promoting metastasis in others—likely due to tissue-specific interactions.
Despite progress, MUSTN1's full functional repertoire remains unclear. Recombinant protein tools are pivotal for unraveling its molecular partners, post-translational modifications, and therapeutic potential. Current research focuses on optimizing delivery systems (e.g., nanoparticles) for MUSTN1-based regenerative therapies and exploring its diagnostic utility as a biomarker for musculoskeletal disorders. Challenges include understanding isoform-specific functions and resolving conflicting roles in different disease models.
×
