Rabbit Polyclonal TGM2 Antibody

Transglutaminase 2 (TG2. or TGM2) is a ubiquitously expressed enzyme that catalyzes calcium-dependent protein crosslinking through transamidation reactions. It plays critical roles in diverse physiological processes, including extracellular matrix stabilization, cell adhesion, apoptosis, and wound healing. In autoimmune contexts, TGM2 is notably linked to celiac disease, where it deamidates gluten peptides, triggering an immune response. This post-translational modification enhances gluten's immunogenicity, leading to the production of anti-TGM2 autoantibodies, which serve as a hallmark diagnostic marker for celiac disease (detected via IgA-class antibodies in serum). Beyond diagnostics, TGM2 antibodies contribute to disease pathology by forming immune complexes that may exacerbate intestinal damage. Research also implicates TGM2 in other conditions, such as fibrosis, neurodegenerative disorders, and cancer, where its dysregulation influences disease progression. Antibodies targeting TGM2 are thus valuable tools for both clinical applications and mechanistic studies, aiding in understanding its multifunctional roles in health and disease. However, their utility outside celiac disease diagnostics remains exploratory, with ongoing studies investigating therapeutic targeting or biomarker potential in oncology and inflammation-related pathologies.