| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CSC-21K |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human TIMP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TIMP2抗体的3篇示例文献(内容为模拟概括，仅供参考)：
1. **文献名称**：*"TIMP-2 Antibody-Based ELISA for Early Detection of Renal Fibrosis"*
**作者**：Smith J, et al.
**摘要**：研究开发了一种高特异性TIMP2抗体ELISA检测方法，用于定量尿液中的TIMP2蛋白水平，发现其在慢性肾病患者的肾纤维化早期诊断中具有潜在临床价值。
2. **文献名称**：*"Monoclonal Antibody Targeting TIMP-2 Suppresses Tumor Invasion in Triple-Negative Breast Cancer Models"*
**作者**：Lee H, et al.
**摘要**：通过体外和动物实验证明，靶向TIMP2的单克隆抗体可通过抑制基质金属蛋白酶(MMPs)的活性，减少肿瘤细胞侵袭和转移，为乳腺癌治疗提供新策略。
3. **文献名称**：*"Immunohistochemical Localization of TIMP-2 in Human Atherosclerotic Plaques"*
**作者**：Garcia-Robles S, et al.
**摘要**：利用TIMP2特异性抗体进行组织染色，发现TIMP2在动脉粥样硬化斑块中的异常表达与血管平滑肌细胞增殖相关，提示其参与病理进展。
**注意**：以上为模拟内容，实际文献需通过PubMed(https://pubmed.ncbi.nlm.nih.gov)或Google Scholar检索关键词如“TIMP2 antibody”、“TIMP2 biomarker”获取。
**Background of TIMP2 Antibody**
Tissue inhibitor of metalloproteinases 2 (TIMP2) is a member of the TIMP family, which regulates extracellular matrix (ECM) remodeling by inhibiting matrix metalloproteinases (MMPs), particularly MMP2 and MMP9. TIMP2 plays a dual role: it not only suppresses protease activity to maintain ECM integrity but also modulates cellular processes like proliferation, apoptosis, and angiogenesis through MMP-independent pathways. Dysregulation of TIMP2 is linked to pathologies such as cancer metastasis, fibrosis, and neurodegenerative disorders.
TIMP2 antibodies are essential tools for detecting and quantifying TIMP2 expression in research and diagnostics. These antibodies enable the study of TIMP2's involvement in tissue homeostasis, disease progression, and therapeutic responses. For example, in cancer, TIMP2 expression correlates with tumor aggressiveness and patient prognosis, while in fibrosis, its loss exacerbates ECM deposition. Antibodies targeting TIMP2 are used in techniques like Western blotting, immunohistochemistry, and ELISA, often requiring validation for specificity against conserved epitopes in the N-terminal inhibitory domain or C-terminal regions.
Recent studies also explore TIMP2's role in aging and metabolic diseases, highlighting its potential as a biomarker or therapeutic target. However, interpretations require caution due to TIMP2's context-dependent functions and cross-reactivity risks with homologous TIMP family members. Overall, TIMP2 antibodies remain pivotal in unraveling the complex biology of ECM regulation and disease mechanisms.
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