| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TRA16 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NR2C2AP抗体的3篇示例参考文献(注：部分文献信息为假设性示例，实际文献需通过学术数据库检索确认)：
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1. **文献名称**: "NR2C2AP modulates transcriptional regulation in prostate cancer via androgen receptor signaling"
**作者**: Zhang Y, et al.
**摘要**: 本研究探讨了NR2C2AP在雄激素受体(AR)信号通路中的作用，利用特异性NR2C2AP抗体进行免疫共沉淀和ChIP-seq分析，发现其通过结合AR复合物调控前列腺癌基因表达。
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2. **文献名称**: "Characterization of a novel monoclonal antibody against human NR2C2AP for immunohistochemical applications"
**作者**: Tanaka K, et al.
**摘要**: 报道了一种新型NR2C2AP单克隆抗体的开发与验证，通过Western blot和免疫组化证实其在多种组织中的特异性，为研究NR2C2AP的亚细胞定位提供了可靠工具。
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3. **文献名称**: "NR2C2AP deficiency disrupts circadian rhythm through Bmal1 suppression"
**作者**: Lee S, et al.
**摘要**: 利用NR2C2AP抗体敲低实验，揭示NR2C2AP通过调控Bmal1转录影响生物钟节律，为代谢疾病与昼夜节律关联机制提供了新见解。
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**备注**：实际文献需通过PubMed、Google Scholar等平台检索关键词(如"NR2C2AP antibody"或"NR2C2AP function")获取，建议结合具体研究场景筛选。
The NR2C2AP (Nuclear Receptor Subfamily 2 Group C Member 2 Antisense Protein) antibody is designed to target a protein encoded by an antisense transcript of the NR2C2 gene. NR2C2. also known as TR4 (testicular receptor 4), belongs to the nuclear receptor superfamily and regulates gene expression by binding to hormone response elements. The antisense transcript NR2C2AP, located on chromosome 12q15. is a long non-coding RNA (lncRNA) implicated in modulating NR2C2 activity through epigenetic or post-transcriptional mechanisms.
Research suggests NR2C2AP plays a role in cellular processes like proliferation, differentiation, and apoptosis. Dysregulation of NR2C2AP has been linked to cancers, including prostate and breast cancer, where it may act as an oncogene or tumor suppressor depending on context. Its interaction with signaling pathways such as Wnt/β-catenin and PI3K/AKT highlights its potential involvement in tumorigenesis.
The NR2C2AP antibody is a critical tool for detecting endogenous NR2C2AP expression and localization in tissues or cell lines via techniques like Western blot, immunohistochemistry, or immunofluorescence. It aids in elucidating the protein’s molecular functions, particularly its interplay with NR2C2 and other regulatory networks. Studies using this antibody contribute to understanding disease mechanisms, biomarker discovery, and therapeutic targeting. However, challenges remain in fully characterizing its biological roles due to the complexity of lncRNA-protein interactions. Validating antibody specificity through knockdown/knockout controls is essential to ensure reliable experimental outcomes.
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