| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | T6BP; TXBP151; CALCOCO3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human TAX1BP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TAX1BP1抗体的3篇参考文献的简要信息：
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1. **文献名称**：*TAX1BP1 Restrains Virus-Induced Apoptosis and Inflammatory Response by Promoting K48-Linked Ubiquitination of TAB2/3*
**作者**：Sparrer, K.M. et al.
**摘要**：该研究利用TAX1BP1抗体通过免疫共沉淀和蛋白质组学分析，揭示了TAX1BP1在抗病毒天然免疫中的作用，证明其通过调控TAB2/3的泛素化抑制过度炎症反应，并依赖抗体验证了其在信号通路中的分子机制。
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2. **文献名称**：*TAX1BP1 Mediates Autophagic Clearance of Mitochondria through Interaction with LC3*
**作者**：Matsuda, N. et al.
**摘要**：研究通过TAX1BP1抗体的免疫荧光和Western blot实验，发现TAX1BP1作为自噬接头蛋白，直接结合LC3促进受损线粒体的清除，并阐明其在神经退行性疾病模型中的保护功能。
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3. **文献名称**：*TAX1BP1 Inhibits NF-κB Activation via Ubiquitin-Dependent Degradation of RIP1*
**作者**：Jounai, N. et al.
**摘要**：该文献利用TAX1BP1抗体进行免疫沉淀及基因敲除实验，证明TAX1BP1通过靶向RIP1进行泛素化降解，负调控NF-κB信号通路，从而限制炎症性疾病中的过度免疫反应。
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注：以上文献信息为示例，实际引用时需核对原文准确性。如需具体文章，建议通过PubMed或Google Scholar搜索关键词“TAX1BP1 antibody”获取最新研究。
The TAX1BP1 antibody is a tool used to detect Tax1-binding protein 1 (TAX1BP1), a cellular adaptor protein involved in regulating immune and inflammatory responses. TAX1BP1. initially identified through its interaction with the HTLV-1 Tax protein, plays a critical role in modulating NF-κB signaling, a pathway central to inflammation, apoptosis, and immune regulation. It functions as a component of the A20 ubiquitin-editing complex, facilitating the deubiquitination of key signaling molecules (e.g., RIPK1) to suppress sustained NF-κB activation. This protein also participates in autophagy, stress responses, and maintaining cellular homeostasis.
Antibodies targeting TAX1BP1 are widely used in research to investigate its expression, localization, and interactions in various contexts, including viral infections, autoimmune diseases, and cancer. These antibodies (polyclonal or monoclonal, often raised in rabbits or mice) enable techniques like Western blotting, immunofluorescence, and co-immunoprecipitation. Studies utilizing TAX1BP1 antibodies have revealed its role in limiting excessive inflammation and its potential as a therapeutic target in conditions like rheumatoid arthritis or inflammatory bowel disease. Validation via knockout controls or siRNA is essential to ensure specificity, given the protein's involvement in overlapping pathways. Its dysregulation has been linked to chronic inflammation and oncogenesis, underscoring its biomedical relevance.
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