| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | T3JAM; DJ434O14.3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human TRAF3IP3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TRAF3IP3抗体的3篇参考文献示例(注：以下内容为模拟生成，非真实文献，仅供格式参考)：
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1. **文献名称**: *TRAF3IP3 modulates TLR signaling by interacting with TRAF3*
**作者**: Smith A, et al.
**摘要**: 本研究开发了一种高特异性的TRAF3IP3多克隆抗体，验证了其在Western blot和免疫共沉淀中的适用性。研究揭示TRAF3IP3通过与TRAF3直接结合，负调控TLR介导的NF-κB激活，为先天免疫反应提供了新机制。
2. **文献名称**: *TRAF3IP3 regulates B cell activation via CD40 signaling*
**作者**: Lee J, et al.
**摘要**: 利用TRAF3IP3单克隆抗体进行免疫荧光和流式分析，发现该蛋白在B细胞中高表达，并参与CD40-TRAF3信号轴。抗体阻断实验表明，TRAF3IP3缺失会导致B细胞增殖异常，提示其作为治疗自身免疫疾病的潜在靶点。
3. **文献名称**: *TRAF3IP3 interacts with viral proteins and promotes innate antiviral response*
**作者**: Zhang Y, et al.
**摘要**: 通过免疫沉淀结合质谱分析(使用TRAF3IP3抗体)，发现该蛋白在病毒感染期间与MAVS蛋白形成复合物，增强I型干扰素产生。抗体介导的功能抑制实验证实了其在抗病毒通路中的关键作用。
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**说明**：上述文献为假设性示例，实际研究中建议通过PubMed或Google Scholar以“TRAF3IP3 antibody”或“TRAF3IP3 function”为关键词检索近期论文，并关注抗体开发、蛋白功能或信号机制相关研究。
The TRAF3IP3 (TRAF3-interacting protein 3) antibody is a tool used to study the role of TRAF3IP3. a protein involved in immune signaling and cellular regulation. TRAF3IP3. also known as IMB-1 or CYBIN, acts as an adaptor molecule that interacts with TRAF3 and other components of signaling pathways, particularly those linked to NF-κB and MAPK cascades. These pathways are critical for regulating inflammatory responses, cell survival, and apoptosis. TRAF3IP3 contains coiled-coil domains that facilitate protein-protein interactions, enabling its function in modulating immune receptor signaling, such as TLRs (Toll-like receptors) and cytokine receptors.
Antibodies targeting TRAF3IP3 are essential for detecting its expression, localization, and post-translational modifications in cells and tissues. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to explore its involvement in diseases, including autoimmune disorders, cancers, and chronic inflammatory conditions. Studies suggest TRAF3IP3 may act as a tumor suppressor in certain contexts or promote inflammation depending on cellular context. Research using these antibodies has also linked TRAF3IP3 dysregulation to aberrant immune activation, making it a potential therapeutic target. Commercial TRAF3IP3 antibodies are typically validated for specificity in human, mouse, or rat samples, aiding mechanistic studies in both basic and translational research.
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