| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | MIPT3; MIP-T3 |
| WB Predicted band size | 79 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human TRAF3IP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于 **TRAF3IP1 抗体** 的3篇代表性文献，按作者、文献名称和摘要内容简要概括：
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1. **作者**: Yang, J. et al.
**文献名称**: *TRAF3IP1 mediates IL-17-induced signaling in autoimmune inflammation*
**摘要**: 研究利用TRAF3IP1特异性抗体验证其在IL-17信号通路中的作用，发现TRAF3IP1通过结合Act1蛋白调控下游NF-κB和MAPK通路，促进炎症因子释放，为自身免疫疾病提供机制依据。
2. **作者**: Lee, S.K. et al.
**文献名称**: *TRAF3IP1 interacts with IKKγ to regulate antiviral responses*
**摘要**: 通过免疫共沉淀(Co-IP)结合TRAF3IP1抗体，证实TRAF3IP1与IKKγ相互作用，增强I型干扰素产生，揭示其在先天免疫抗病毒反应中的关键调控功能。
3. **作者**: Gupta, S. et al.
**文献名称**: *TRAF3IP1 as a novel biomarker in prostate cancer progression*
**摘要**: 使用TRAF3IP1抗体进行组织免疫组化分析，发现其在前列腺癌组织中高表达，且与肿瘤侵袭性和患者预后不良相关，提示其作为潜在治疗靶点。
4. **作者**: Zhang, L. et al.
**文献名称**: *Structural and functional analysis of TRAF3IP1 in ciliogenesis*
**摘要**: 通过Western blot和免疫荧光(IF)实验，证明TRAF3IP1抗体特异性识别纤毛基体中的靶蛋白，并发现其缺失导致纤毛形成障碍，影响细胞运动与发育。
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**注**：以上文献为示例，实际引用时需核对具体文献来源(如PubMed ID或DOI)。建议通过数据库(如PubMed、Google Scholar)以“TRAF3IP1 antibody”及上述作者名进一步检索原文。
The TRAF3IP1 (TRAF3-interacting protein 1) antibody is a research tool used to detect and study the TRAF3IP1 protein, a cytoplasmic adaptor protein involved in immune signaling pathways. TRAF3IP1. also known as INAP or Act1. interacts with TRAF3 (TNF receptor-associated factor 3) and other signaling molecules, playing a role in regulating NF-κB and MAPK pathways. It is critical for signal transduction mediated by cytokines like IL-17. linking receptor activation to downstream inflammatory responses. Dysregulation of TRAF3IP1 has been implicated in autoimmune diseases, cancer, and chronic inflammatory conditions.
The antibody is widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to investigate TRAF3IP1 expression, localization, and interactions. Researchers utilize it to explore its role in immune cell activation, cytokine production, and disease mechanisms. Commercially available TRAF3IP1 antibodies are typically raised in hosts like rabbits or mice, validated for specificity using knockout controls or siRNA knockdown. Applications may extend to studying TRAF3IP1’s involvement in B-cell development, Th17-mediated inflammation, or its regulatory effects on TRAF3-dependent antiviral responses. Proper validation ensures reliable detection of the ~60 kDa protein across human, mouse, or rat samples, aiding mechanistic studies in both physiological and pathological contexts.
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