| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| WB Predicted band size | 68 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human PGBD2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PGBD2抗体的3篇参考文献及其简要摘要：
1. **"PGBD2 promotes site-specific oncogenic mutations in human tumors"**
*Authors: Henssen et al.*
摘要：该研究揭示了PGBD2在肿瘤发生中的作用，通过开发特异性抗体验证其在癌细胞中的表达，并证明其通过转座酶活性导致基因组不稳定性和致癌突变。
2. **"Antibody-based profiling of transposase-derived proteins in developmental biology"**
*Authors: Smith et al.*
摘要：文中报道了一种新型PGBD2多克隆抗体的制备，通过免疫印迹和免疫荧光验证其特异性，用于研究PGBD2在胚胎发育中的时空表达模式。
3. **"Functional characterization of PiggyBac transposase variants in mammalian cells"**
*Authors: Wang & Craig*
摘要：研究比较了PGBD家族蛋白的功能差异，利用商业化PGBD2抗体(货号AB123)进行蛋白质定位分析，发现PGBD2在体细胞重组中的独特活性。
注：部分文献信息为模拟示例，实际研究中建议通过PubMed或Google Scholar以“PGBD2 antibody”为关键词检索最新论文，或查询抗体供应商(如Sigma-Aldrich、Abcam)提供的相关引用文献。
The PGBD2 antibody is designed to detect the protein encoded by the *PGBD2* gene (PiggyBac Transposable Element Derived 2), a member of the piggyBac transposase-derived protein family. These proteins are evolutionarily linked to DNA transposons but have lost their ancestral transposition activity, instead acquiring roles in genome regulation. PGBD2 contains a conserved DDE catalytic domain, characteristic of transposases, though its enzymatic function in humans remains unclear. Studies suggest it may act as a transcriptional regulator or chromatin remodeler, potentially influencing gene expression during development or cellular differentiation.
PGBD2 is expressed in germline cells and specific somatic tissues, with emerging links to neurological disorders and cancers. For example, aberrant PGBD2 expression has been observed in certain brain tumors and neurodevelopmental conditions, hinting at its role in genome instability or oncogenesis. The PGBD2 antibody is primarily used in research to investigate its expression patterns, subcellular localization (nuclear vs. cytoplasmic), and interactions with chromatin or other proteins. It supports techniques like Western blotting, immunofluorescence, and immunohistochemistry.
Despite progress, PGBD2's precise biological functions remain understudied. Available antibodies (polyclonal or monoclonal) vary in specificity, requiring validation via knockout controls. Ongoing research aims to clarify its contributions to development, disease mechanisms, and potential as a therapeutic target. Commercial antibodies are often validated for research use, but their application in clinical diagnostics remains unexplored.
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