| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MCP; AFCP |
| WB Predicted band size | 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CAPG |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CAPG抗体的3篇参考文献示例(注：以下内容为模拟生成，仅供参考)：
1. **文献名称**: "CAPG as a Biomarker in Triple-Negative Breast Cancer: Immunohistochemical Analysis Using a Novel Monoclonal Antibody"
**作者**: Smith, J.R., et al.
**摘要**: 该研究开发了一种新型抗CAPG单克隆抗体，并通过免疫组化分析发现CAPG在三阴性乳腺癌组织中高表达，与肿瘤转移和不良预后显著相关。结果表明CAPG可能作为潜在的治疗靶点或诊断标志物。
2. **文献名称**: "Autoantibodies to Cytoskeletal Protein CAPG in Rheumatoid Arthritis: Clinical Associations and Pathogenic Role"
**作者**: Tanaka, M., et al.
**摘要**: 研究检测了类风湿性关节炎(RA)患者血清中的CAPG自身抗体水平，发现其与疾病活动度和关节破坏程度呈正相关。实验表明CAPG抗体可能通过激活NF-κB通路加剧炎症反应，提示其在RA发病机制中的作用。
3. **文献名称**: "Development of a High-Sensitivity ELISA for CAPG Detection in Pancreatic Cancer Serum Samples"
**作者**: Wang, L., et al.
**摘要**: 该团队利用CAPG多克隆抗体建立了一种高灵敏度ELISA检测方法，证实胰腺癌患者血清CAPG水平显著高于健康对照组，且与肿瘤分期相关。该方法为无创诊断胰腺癌提供了新策略。
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*注：以上文献信息为示例性模拟，实际研究中请通过学术数据库(如PubMed、Web of Science)以关键词“CAPG antibody”“CAPG biomarker”等检索最新文献。*
CAPG (macrophage-capping protein) is an actin-binding protein belonging to the gelsolin superfamily, primarily involved in regulating actin filament dynamics. It modulates cell membrane architecture, motility, and intracellular trafficking by capping the barbed ends of actin filaments, thereby stabilizing cytoskeletal structures. CAPG is expressed in various tissues, with notable roles in immune cells (e.g., macrophages, neutrophils) and cancer cells. Its dual localization in the cytoplasm and nucleus suggests additional functions in transcriptional regulation and chromatin remodeling.
CAPG antibodies are widely used in research to investigate its expression patterns and mechanistic roles. Overexpression of CAPG has been linked to tumor progression, metastasis, and poor prognosis in cancers such as breast, prostate, and colorectal cancer, making it a potential biomarker or therapeutic target. In immunology, CAPG antibodies help study its involvement in inflammatory responses and phagocytosis.
Commercially available CAPG antibodies are developed for techniques like Western blotting, immunohistochemistry, and immunofluorescence. However, specificity validation remains crucial due to structural similarities within the gelsolin family. Recent studies also explore CAPG's interaction with viral pathogens and its role in neurodegenerative diseases, expanding its relevance in biomedical research.
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