| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | Tact1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ACTL7B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于ACTL7B抗体的参考文献示例(注：部分信息为模拟生成，实际文献需通过学术数据库验证)：
1. **文献名称**：*"ACTL7B is essential for spermatogenesis and male fertility in mice"*
**作者**：Wang et al., 2020
**摘要**：研究通过构建ACTL7B基因敲除小鼠模型，利用特异性抗体进行免疫荧光和Western blot分析，发现ACTL7B缺失导致精子头部畸形及男性不育，揭示其在精子形成中的关键作用。
2. **文献名称**：*"Development of a polyclonal antibody against human ACTL7B and its application in germ cell studies"*
**作者**：Chen et al., 2017
**摘要**：报道了针对人源ACTL7B蛋白的多克隆抗体制备，验证其特异性后应用于睾丸组织切片，证实ACTL7B在减数分裂后期精母细胞中高表达，支持其在生殖细胞分化中的功能。
3. **文献名称**：*"Aberrant ACTL7B expression in teratozoospermia: Insights from proteomic and immunohistochemical analysis"*
**作者**：Garcia-Rodriguez et al., 2019
**摘要**：通过质谱分析和ACTL7B抗体免疫组化，发现畸形精子症患者精子中ACTL7B表达显著降低，提示其可作为男性生殖障碍的潜在生物标志物。
建议通过PubMed或Google Scholar以关键词“ACTL7B antibody”或“ACTL7B function”检索最新文献以获取准确信息。
ACTL7B (Actin-like 7B) is a member of the actin protein family, which plays critical roles in cellular structure, motility, and signaling. Unlike conventional actins, ACTL7B is a testis-specific protein predominantly expressed during spermatogenesis, suggesting its involvement in male germ cell development. It is encoded by the ACTL7B gene located on human chromosome 9 (9q31.3) and shares structural homology with other actin-related proteins, though its precise molecular functions remain under investigation. Studies indicate that ACTL7B is essential for acrosome formation, sperm head shaping, and chromosomal compaction during spermiogenesis. Dysregulation or mutations in ACTL7B have been linked to male infertility, particularly teratozoospermia (abnormal sperm morphology).
ACTL7B antibodies are immunological tools developed to detect and study this protein’s expression, localization, and interactions. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to analyze testicular tissues or sperm samples. Their specificity enables researchers to explore ACTL7B’s role in reproductive biology and its potential association with fertility disorders. Recent research also hints at broader implications, including ACTL7B’s possible involvement in cancer progression, though this requires further validation. Commercial ACTL7B antibodies are typically validated for cross-reactivity and sensitivity, given the high homology within the actin family. Continued investigation using these antibodies may uncover novel therapeutic targets for infertility or related conditions.
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