| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CT57 |
| WB Predicted band size | 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ACTL8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ACTL8抗体的示例参考文献(注：以下内容为假设性示例，实际文献需通过学术数据库检索)：
1. **文献名称**: "ACTL8 Expression and Antibody Development in Human Cancer Tissues"
**作者**: Zhang Y, et al.
**摘要**: 本研究开发了一种针对ACTL8蛋白的单克隆抗体，验证了其在多种癌症组织中的特异性表达，并发现ACTL8在乳腺癌中的高表达与患者预后不良相关。
2. **文献名称**: "Functional Characterization of ACTL8 in Neuronal Development Using CRISPR/Cas9 and Immunostaining"
**作者**: Lee S, et al.
**摘要**: 通过CRISPR/Cas9敲除ACTL8基因并利用特异性抗体进行免疫荧光分析，揭示了ACTL8在神经元突触形成中的关键作用及其与细胞骨架重塑的关系。
3. **文献名称**: "ACTL8 Antibody Validation for Flow Cytometry in Immune Cell Profiling"
**作者**: Müller F, et al.
**摘要**: 报道了一种经过验证的ACTL8多克隆抗体，可用于流式细胞术检测免疫细胞亚群中ACTL8的表达水平，并证实其与T细胞活化相关。
4. **文献名称**: "ACTL8 as a Novel Biomarker in Ovarian Cancer: Clinical Implications of Antibody-Based Detection"
**作者**: Gupta R, et al.
**摘要**: 研究利用ACTL8特异性抗体对卵巢癌组织进行免疫组化分析，发现ACTL8可作为潜在诊断标志物，并探讨其参与肿瘤侵袭的分子机制。
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建议通过PubMed、Google Scholar或Web of Science检索真实文献(关键词：ACTL8 antibody, ACTL8 function)，并注意选择近5年内的研究以确保时效性。
ACTL8 (actin-like 8) is a member of the actin-related protein (ARP) family, which shares structural homology with conventional actins but performs specialized functions in cellular processes. The ACTL8 gene encodes a protein containing conserved actin-fold domains and a unique N-terminal coiled-coil region, suggesting roles in molecular interactions or structural organization. While its precise biological function remains under investigation, ACTL8 is implicated in regulating cytoskeletal dynamics, chromatin remodeling, and intracellular transport, often through forming complexes with other ARPs or binding partners like ATPases or histone modifiers.
ACTL8 antibodies are valuable tools for studying its expression patterns, subcellular localization (e.g., cytoplasmic or nuclear), and involvement in diseases. Research links ACTL8 to cancer progression, where its dysregulation may influence cell proliferation, migration, or genomic instability. Antibody-based techniques (e.g., Western blot, immunofluorescence, or IP) have been employed to explore its interactions in pathways such as the SWI/SNF chromatin-remodeling complex. Recent studies also suggest potential roles in neurodevelopment or immune regulation, though mechanistic details are limited. Commercial ACTL8 antibodies are typically validated for specificity using knockout controls. Further research is needed to clarify its physiological and pathological significance across tissues.
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