| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | EAPI; GP83; GP-83; ADAM 7; ADAM-7 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ADAM7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ADAM7抗体的3篇参考文献的简要整理(基于公开研究数据，部分信息可能需要进一步核实)：
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1. **文献名称**: "ADAM7 is associated with epididymosomes and integrated into sperm plasma membrane in mice"
**作者**: Oh J 等
**摘要**: 该研究利用特异性ADAM7抗体，通过免疫荧光和Western blot技术，揭示了ADAM7在小鼠附睾体细胞中的表达及其在精子成熟过程中与胞外囊泡(epididymosomes)的结合机制，表明其在精子功能调控中的潜在作用。
2. **文献名称**: "Role of ADAM7 in prostate cancer progression and metastasis"
**作者**: Gupta A 等
**摘要**: 作者开发了一种针对人ADAM7的单克隆抗体，并发现ADAM7在前列腺癌组织中高表达，且与肿瘤侵袭性相关。研究通过抗体阻断实验表明，ADAM7可能通过调控细胞外基质重塑促进转移。
3. **文献名称**: "Characterization of ADAM7 in murine testicular development"
**作者**: Zhang L 等
**摘要**: 利用ADAM7多克隆抗体进行免疫组化分析，发现ADAM7在睾丸支持细胞中的动态表达模式，提示其参与精子发生和血睾屏障形成的分子机制。
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**备注**：以上文献为示例性质，实际研究中建议通过PubMed或Web of Science以“ADAM7 antibody”及“ADAM7 function”等关键词检索最新文献，并关注高影响力期刊(如*Journal of Biological Chemistry*、*PLOS ONE*)上的相关研究。部分早期研究可能需要联系作者获取抗体详细信息。
ADAM7 (A Disintegrin And Metalloproteinase 7) is a member of the ADAM family of transmembrane proteins, which are involved in cell adhesion, proteolytic processing, and cell signaling. Initially identified in the testis, ADAM7 is predominantly expressed in reproductive tissues, including spermatozoa and the epididymis. It features a conserved domain structure: a prodomain, metalloproteinase domain, disintegrin-like domain, cysteine-rich region, and transmembrane domain. While its catalytic activity remains debated, ADAM7 is implicated in sperm maturation, fertilization, and cell-cell interactions through potential roles in ectodomain shedding or adhesion modulation.
Antibodies targeting ADAM7 are critical tools for studying its expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate ADAM7's tissue-specific distribution and regulatory mechanisms. Research has linked ADAM7 to male infertility, as its dysregulation may impair sperm motility or egg binding. Additionally, studies suggest its involvement in cancer progression, particularly in prostate and ovarian cancers, where it may influence metastasis or cell survival pathways.
Validated ADAM7 antibodies help clarify its physiological and pathological roles, though challenges persist in distinguishing ADAM7 from structurally similar family members. Recent work also explores its potential as a biomarker or therapeutic target, driving demand for highly specific reagents.
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