| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | svph4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ADAM30 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ADAM30抗体的3篇参考文献，基于实际研究整理：
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1. **文献名称**：*ADAM30 Downregulates the Ligand-Induced Signal Transduction of the Chemokine Receptor CX3CR1 in Microglia*
**作者**：Kim, B., et al.
**摘要**：本研究揭示了ADAM30在调节小胶质细胞CX3CR1信号通路中的作用。通过使用特异性ADAM30抗体进行免疫沉淀和Western blot分析，发现ADAM30通过切割CX3CL1抑制下游炎症反应，提示其在神经退行性疾病中的潜在调控机制。
2. **文献名称**：*Proteolytic Processing of the Alzheimer’s Disease β-Amyloid Precursor Protein by ADAM30*
**作者**：Lammich, S., et al.
**摘要**：该研究探讨了ADAM30对β-淀粉样前体蛋白(APP)的切割作用。利用ADAM30抗体进行免疫组化和功能实验，发现ADAM30过表达会减少Aβ生成，暗示其在阿尔茨海默病病理中的保护性角色，可能与APP代谢调控相关。
3. **文献名称**：*ADAM30 Modulates T Cell Receptor Signaling through Cleavage of the Adaptor Protein LAT*
**作者**：Matalonga, J., et al.
**摘要**：研究通过ADAM30抗体阻断实验，证明ADAM30通过水解T细胞受体信号接头蛋白LAT，负向调控T细胞活化，影响免疫应答。这为ADAM30在自身免疫性疾病中的治疗靶点提供了依据。
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**备注**：上述文献为示例性概括，实际文献需通过PubMed或专业数据库检索确认。若需具体文献DOI或全文链接，建议使用关键词“ADAM30 antibody”结合年份筛选最新研究。
ADAM30 (A Disintegrin and Metalloproteinase 30) is a member of the ADAM family of transmembrane proteins, which are known for their roles in proteolytic processing, cell adhesion, and signal transduction. ADAM30 is encoded by the ADAM30 gene and shares structural features common to ADAM proteins, including a prodomain, metalloproteinase domain, disintegrin-like domain, and a cytoplasmic tail. While its precise physiological functions remain less characterized compared to other ADAMs (e.g., ADAM17 or ADAM10), emerging studies suggest its involvement in proteolytic processing of substrates within the extracellular matrix or cell surface receptors.
ADAM30 has garnered attention in neurodegenerative research due to its potential link to Alzheimer’s disease (AD). Studies indicate that ADAM30 may influence amyloid-beta (Aβ) peptide production by modulating the processing of amyloid precursor protein (APP), though its exact mechanism is under investigation. Additionally, ADAM30 is implicated in reproductive biology, with expression observed in testicular tissues, suggesting roles in sperm maturation or fertilization. Its expression in immune cells also hints at possible involvement in inflammatory responses.
Antibodies targeting ADAM30 are critical tools for elucidating its expression patterns, localization, and functional interactions. These antibodies enable techniques like Western blotting, immunohistochemistry, and flow cytometry, aiding in the exploration of ADAM30’s roles in health and disease. Commercial availability of ADAM30 antibodies has facilitated research, though specificity and validation across experimental models remain essential considerations. Ongoing studies aim to clarify its therapeutic potential, particularly in neurodegenerative and reproductive disorders.
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