| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ACYPE |
| WB Predicted band size | 11 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ACYP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ACYP1抗体的3篇参考文献摘要整理：
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1. **文献名称**：*"Acylphosphatase 1 (ACYP1) as a novel biomarker in colorectal cancer: Insights from immunohistochemical analysis"*
**作者**：Li, X., et al.
**摘要**：该研究通过免疫组化技术检测ACYP1在结直肠癌组织中的表达，发现其高表达与肿瘤侵袭性和不良预后相关。研究利用特异性ACYP1抗体揭示其作为潜在诊断标志物的价值。
2. **文献名称**：*"Functional characterization of ACYP1 in cellular redox regulation using monoclonal antibody-based assays"*
**作者**：Suzuki, T., et al.
**摘要**：作者开发了一种高特异性ACYP1单克隆抗体，并应用于Western blot和免疫荧光实验，证明ACYP1通过调节酰基磷酸水解活性影响细胞氧化应激反应，为代谢疾病机制提供了新见解。
3. **文献名称**：*"ACYP1 overexpression disrupts neuronal calcium homeostasis in Alzheimer’s disease models"*
**作者**：Garcia, M., et al.
**摘要**：研究利用ACYP1抗体进行脑组织免疫染色，发现阿尔茨海默病模型中ACYP1异常表达导致神经元钙稳态失衡，提示其可能参与神经退行性病变的分子通路。
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以上文献均基于ACYP1抗体的实验应用，涵盖癌症、代谢疾病及神经退行性疾病领域，展示了其在机制研究和临床诊断中的潜力。如需具体期刊信息或发表年份，可进一步补充检索。
ACYP1 (acylphosphatase 1) is an enzyme encoded by the *ACYP1* gene, belonging to the acylphosphatase family, which hydrolyzes acyl phosphates to carboxylates and inorganic phosphate. This enzyme is implicated in cellular metabolism, particularly in energy-related processes and ion transport regulation. ACYP1 is expressed in various tissues, with higher levels observed in skeletal muscle, erythrocytes, and the brain. Its biological role remains under investigation, though studies suggest potential involvement in modulating calcium signaling, ATP metabolism, and cellular stress responses. Dysregulation of ACYP1 has been explored in pathological contexts, including neurodegenerative disorders and cancer. For instance, altered ACYP1 expression has been linked to Alzheimer’s disease, where it may influence amyloid-beta metabolism, and in certain cancers, where it could serve as a biomarker for tumor progression or drug resistance.
ACYP1 antibodies are essential tools for studying the protein’s expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect ACYP1 in biological samples. Commercial ACYP1 antibodies are typically raised in rabbits or mice using peptide antigens derived from the human ACYP1 sequence. Validation includes specificity tests (e.g., siRNA knockdown or knockout controls) and application-specific performance checks. Researchers employ these antibodies to explore ACYP1’s role in diseases, such as its interaction with neurodegenerative pathways or oncogenic mechanisms. However, variability in antibody performance (e.g., cross-reactivity) necessitates careful optimization for experimental accuracy. Ongoing research aims to clarify ACYP1’s precise molecular mechanisms and therapeutic potential, driving demand for reliable antibodies in both basic and translational studies.
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