| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ALDH4; ALDH7 |
| WB Predicted band size | 52 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ALDH3B1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ALDH3B1抗体的3篇参考文献，按文献名称、作者和摘要内容概括列出：
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1. **"Aldehyde dehydrogenase 3B1 (ALDH3B1) promotes cellular resistance to oxidative stress in hepatocellular carcinoma"**
*Authors: Chen Y, et al.*
摘要：研究利用ALDH3B1特异性抗体，通过免疫组化分析发现ALDH3B1在肝癌组织中高表达，其通过清除氧化应激产物(如4-HNE)增强癌细胞存活能力，提示其作为肝癌治疗潜在靶点。
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2. **"ALDH3B1 as a prognostic biomarker in non-small cell lung cancer: Immunohistochemical analysis using a novel monoclonal antibody"**
*Authors: Smith RJ, et al.*
摘要：开发了一种新型ALDH3B1单克隆抗体，验证其在非小细胞肺癌(NSCLC)组织中的特异性。研究发现ALDH3B1高表达与患者不良预后相关，可能通过调控肿瘤干细胞特性促进转移。
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3. **"Differential expression of ALDH3B1 isoforms in breast cancer and their interaction with chemotherapeutic agents"**
*Authors: Gupta S, et al.*
摘要：通过Western blot和免疫荧光(使用ALDH3B1抗体)发现乳腺癌细胞中ALDH3B1存在两种亚型，其中一种亚型与化疗耐药性相关，机制涉及代谢解毒途径的激活。
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**备注**：以上文献名为示例，实际研究中建议通过PubMed或Web of Science搜索具体文献。若需全文，可使用DOI或联系作者获取。
The aldehyde dehydrogenase 3 family member B1 (ALDH3B1) is an enzyme belonging to the ALDH superfamily, which plays a critical role in detoxifying endogenous and exogenous aldehydes by oxidizing them into carboxylic acids. ALDH3B1 is implicated in cellular defense against oxidative stress, metabolic regulation, and potential involvement in diseases such as cancer, neurodegenerative disorders, and alcohol-related pathologies. Its expression varies across tissues, with higher levels observed in the liver, kidneys, and respiratory tract.
ALDH3B1 antibodies are essential tools for detecting and quantifying ALDH3B1 protein expression in research applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies aid in studying ALDH3B1's physiological roles, including its contribution to drug resistance in cancers, metabolic reprogramming, and response to oxidative damage. Commercially available ALDH3B1 antibodies are typically developed using immunogens derived from specific peptide sequences or recombinant proteins, ensuring specificity through validation in knockdown models or ALDH3B1-deficient cell lines.
Research utilizing ALDH3B1 antibodies has revealed its dual role as both a detoxifying enzyme and a potential biomarker. For instance, elevated ALDH3B1 levels are linked to poor prognosis in certain cancers, suggesting its utility in diagnostic or therapeutic strategies. However, functional studies remain limited, highlighting the need for further exploration of its mechanistic pathways. Reliable antibodies are thus critical for advancing understanding of ALDH3B1's multifunctional biology and its implications in disease pathogenesis.
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