| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human AMZ2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于AMZ2抗体的3篇参考文献示例(注：AMZ2相关研究较少，以下内容为假设性示例，实际文献需通过学术数据库查询)：
1. **文献名称**：*AMZ2 regulates neuronal development via endosomal trafficking*
**作者**：Smith A, et al.
**摘要**：本研究开发了一种兔源多克隆AMZ2抗体，用于探究AMZ2蛋白在小鼠大脑皮层神经元中的功能。通过免疫组化和Western blot验证了抗体的特异性，发现AMZ2通过调控早期内体运输影响神经突触形成。
2. **文献名称**：*AMZ2 interacts with Wnt signaling components in colorectal cancer*
**作者**：Li J, et al.
**摘要**：文章报道了一种商业化小鼠单克隆AMZ2抗体的应用，通过免疫共沉淀(Co-IP)实验证实AMZ2与β-catenin存在物理相互作用，提示其在结直肠癌Wnt通路异常激活中可能起调控作用。
3. **文献名称**：*Characterization of AMZ2 knockout mice using novel polyclonal antibodies*
**作者**：Garcia R, et al.
**摘要**：研究团队制备了针对AMZ2 C端结构域的多克隆抗体，通过免疫荧光和流式细胞术分析发现，AMZ2基因敲除小鼠的肝细胞中自噬相关蛋白LC3-II表达显著升高，表明AMZ2可能参与自噬调控。
(提示：实际研究中AMZ2相关文献较少，建议通过UniProt查询AMZ2蛋白结构域信息，或关注其同源蛋白研究;若需具体文献，请提供更完整的基因别名或研究背景。)
AMZ2 (Archipelago Homolog 2), also known as RNF216P1. is a gene encoding a protein with a RING finger domain, suggesting its potential role in ubiquitination and protein degradation processes. Initially identified through homology to the Drosophila archipelago gene, AMZ2 is implicated in regulating cell cycle progression and signal transduction pathways. Studies indicate its interaction with components of the E3 ubiquitin ligase complex, which targets specific proteins for proteasomal degradation, influencing cellular processes like apoptosis and proliferation.
Research on AMZ2 has gained attention due to its possible involvement in neurological disorders and cancer. For instance, dysregulation of AMZ2 expression has been observed in certain tumors, linking it to oncogenic or tumor-suppressive roles depending on cellular context. Additionally, its homolog RNF216 is associated with neurodegenerative conditions like Gordon Holmes syndrome, hinting at AMZ2's potential relevance in neural health.
The AMZ2 antibody is a critical tool for investigating these functions. It enables detection and quantification of AMZ2 protein levels in tissues or cell lines via techniques like Western blotting, immunohistochemistry, or immunofluorescence. Researchers use it to explore AMZ2's localization, interaction partners, and expression patterns under various physiological or pathological conditions. Its development supports ongoing efforts to clarify AMZ2's mechanistic contributions to disease pathways and therapeutic potential.
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