| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | ALEX3; dJ545K15.2 |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ARMCX3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于ARMCX3抗体的3篇参考文献(注：部分内容为示例性概括，实际文献需通过学术数据库核实)：
1. **"ARMCX3 regulates mitochondrial trafficking and promotes invasive migration in malignant glioma"**
- 作者：Li, Y., et al.
- 摘要：本研究通过免疫组化(IHC)和Western blot(WB)验证了ARMCX3抗体在胶质瘤细胞系中的特异性，发现ARMCX3通过调控线粒体动态分布促进肿瘤细胞侵袭迁移。
2. **"Expression profiling of ARMCX family proteins in colorectal cancer using a novel monoclonal antibody panel"**
- 作者：Zhang, H., et al.
- 摘要：作者开发了针对ARMCX家族(包括ARMCX3)的特异性单克隆抗体，通过免疫荧光和流式细胞术证实ARMCX3在结直肠癌中高表达，并与患者预后不良相关。
3. **"ARMCX3 interacts with α-tubulin to modulate Wnt signaling in neural development"**
- 作者：Garcia, M., et al.
- 摘要：利用ARMCX3抗体进行免疫共沉淀(Co-IP)实验，揭示了ARMCX3与微管蛋白的相互作用，并发现其通过Wnt/β-catenin通路影响神经前体细胞分化。
(注：以上文献为示例性内容，实际引用时建议通过PubMed或Google Scholar以“ARMCX3 antibody”为关键词检索近期论文，重点关注抗体应用场景如WB/IHC/IF等实验验证数据。)
The ARMCX3 (Armadillo repeat-containing X-linked protein 3) antibody is a tool used to study the ARMCX3 protein, a member of the ARMCX family implicated in mitochondrial dynamics and cellular processes. ARMCX3. located on the X chromosome, encodes a protein with six predicted transmembrane domains and Armadillo repeats, suggesting roles in protein-protein interactions or membrane-associated functions. While its exact biological role remains under investigation, ARMCX3 is hypothesized to regulate mitochondrial transport, morphology, or metabolism, particularly in neurons, given its homology to other mitochondrial proteins. Dysregulation of ARMCX3 has been linked to neurological disorders and cancers, such as glioblastoma, where it may influence tumor progression via metabolic pathways.
ARMCX3 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. These antibodies enable detection of ARMCX3 in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validation often includes confirming specificity through knockout/knockdown cell lines or tissue samples. Researchers utilize these antibodies to explore ARMCX3's expression patterns, subcellular localization (e.g., mitochondrial association), and interactions with signaling pathways. As ARMCX3 is part of a larger protein family with overlapping functions, careful experimental controls are essential to distinguish its role from related proteins like ARMCX1 or ARMCX5. Its study contributes to understanding mitochondrial biology and disease mechanisms.
×
