| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | GEF3; STA3; XPLN |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ARHGEF3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ARHGEF3抗体的模拟参考文献示例(注：内容为虚构，建议通过学术数据库核实真实文献)：
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1. **文献名称**: *ARHGEF3 regulates osteoclast differentiation via RhoA activation*
**作者**: Yamamoto A, et al.
**摘要**: 本研究利用ARHGEF3特异性抗体(克隆号：sc-123)通过Western blot和免疫荧光分析，揭示了ARHGEF3在破骨细胞分化过程中通过激活RhoA信号通路调控细胞骨架重塑的作用。
2. **文献名称**: *ARHGEF3 expression in human platelets and its role in thrombus formation*
**作者**: Chen L, et al.
**摘要**: 通过流式细胞术和免疫沉淀技术(使用兔源ARHGEF3多克隆抗体，Abcam #ab789)，作者证实ARHGEF3在血小板中高表达，并参与调控凝血过程中Rho GTP酶的动态平衡。
3. **文献名称**: *ARHGEF3 as a novel biomarker in hepatocellular carcinoma progression*
**作者**: Wang X, et al.
**摘要**: 采用ARHGEF3抗体(货号：HPA045632)对肝癌组织进行免疫组化分析，发现其表达水平与肿瘤侵袭性呈正相关，提示其可能作为预后标志物。
4. **文献名称**: *ARHGEF3 knockdown inhibits melanoma cell migration via JNK pathway suppression*
**作者**: Rodriguez S, et al.
**摘要**: 研究通过siRNA沉默ARHGEF3并结合抗体(Santa Cruz #sc-55500)验证蛋白敲低效果，证明ARHGEF3通过调控JNK信号通路影响黑色素瘤细胞的迁移能力。
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建议通过**PubMed**或**Google Scholar**以关键词“ARHGEF3 antibody + application”检索真实文献，或查阅抗体供应商(如Abcam、CST)的产品引用列表获取具体研究。
The ARHGEF3 antibody is a research tool designed to detect and study the ARHGEF3 protein, a member of the Rho guanine nucleotide exchange factor (RhoGEF) family. ARHGEF3. also known as XPLN, regulates Rho GTPase signaling by activating RhoA and RhoB, which are critical for cytoskeletal dynamics, cell adhesion, and motility. This protein contains a DH (Dbl homology) domain responsible for catalyzing GTP/GDP exchange and a PH (pleckstrin homology) domain involved in membrane targeting. ARHGEF3 is implicated in diverse physiological and pathological processes, including cancer metastasis, fibrosis, and bone metabolism, making it a focus in studies on cell signaling and disease mechanisms.
The ARHGEF3 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and regulation. Researchers employ it to explore ARHGEF3's role in TGF-β-mediated pathways, platelet activation, and osteoclast differentiation. Dysregulation of ARHGEF3 has been linked to conditions such as liver fibrosis, osteoporosis, and tumor progression, highlighting its potential as a therapeutic target. Validated for specificity and sensitivity, this antibody aids in elucidating how ARHGEF3 modulates Rho-dependent signaling cascades, offering insights into cellular responses to mechanical and biochemical cues. Its application advances understanding of diseases driven by aberrant Rho GTPase activity.
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