| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | ARP2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ACTR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ACTR2抗体的3篇参考文献示例(注：文献为虚构示例，仅用于演示格式)：
1. **文献名称**：*"ACTR2 Antibody Characterization in the Study of Actin Polymerization Dynamics"*
**作者**：Smith J, et al.
**摘要**：本研究利用特异性ACTR2抗体探究了ARP2/3复合体在肌动蛋白成核中的作用。通过免疫沉淀和Western blot验证了抗体在HeLa细胞中的特异性，揭示了ACTR2在细胞迁移中的关键调控机制。
2. **文献名称**：*"Development of a Monoclonal Antibody Targeting ACTR2 for Cancer Cell Motility Analysis"*
**作者**：Lee H, et al.
**摘要**：开发了一种高亲和力ACTR2单克隆抗体，用于检测乳腺癌细胞中ARP2/3复合体的亚细胞定位。通过免疫荧光证实了ACTR2在侵袭性伪足中的富集，为癌症转移研究提供了工具。
3. **文献名称**：*"ACTR2-Specific Antibody Reveals Its Role in Neuronal Morphogenesis"*
**作者**：Garcia R, et al.
**摘要**：利用ACTR2特异性抗体在小鼠神经元中研究其功能，发现ACTR2缺失导致树突棘发育异常，表明其在突触形成中具有重要作用。
(注：以上文献为模拟内容，实际文献需通过PubMed或Google Scholar以关键词“ACTR2 antibody”或“ARP2/3 complex antibody”检索。)
The ACTR2 antibody targets Actin-Related Protein 2 (ACTR2), a key component of the ARP2/3 complex, which plays a critical role in regulating actin cytoskeleton dynamics. The ARP2/3 complex facilitates actin nucleation, branching, and reorganization, processes essential for cell motility, membrane trafficking, and cytokinesis. ACTR2. along with ARP3. forms the structural core of this complex, enabling it to bind existing actin filaments and nucleate new branches, thereby driving cellular shape changes and movement. Dysregulation of ACTR2 or the ARP2/3 complex is implicated in pathological conditions, including cancer metastasis, immune cell dysfunction, and neurological disorders.
ACTR2 antibodies are widely used in research to study actin polymerization mechanisms, cell migration, and intracellular transport. They are employed in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to visualize ACTR2 expression, localization, and interactions. Commercially available ACTR2 antibodies are typically raised in rabbits or mice, with validation across species like humans, mice, and rats. These tools have advanced understanding of how cytoskeletal remodeling contributes to developmental processes, infection pathways (e.g., pathogen invasion), and metastatic behaviors in tumors. Ongoing research continues to explore ACTR2 as a potential therapeutic target for diseases linked to cytoskeletal abnormalities.
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