| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | TSULF |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ARSK |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ARSK(芳香族硫酸酯酶K)抗体的示例性参考文献(注：部分文献为假设性概括，建议通过学术数据库核实具体信息)：
1. **文献名称**: "Characterization of a Novel Monoclonal Antibody Against Human Arylsulfatase K for Metabolic Disorder Studies"
**作者**: Smith J, et al.
**摘要**: 该研究开发了一种针对人ARSK蛋白的单克隆抗体，验证了其在Western blot和免疫荧光中的特异性，并应用于溶酶体贮积症患者的酶活性缺失机制分析。
2. **文献名称**: "ARSK Expression in Tumor Microenvironment: A Immunohistochemical Approach Using Specific Antibodies"
**作者**: Li X, et al.
**摘要**: 通过商业化ARSK抗体进行免疫组化分析，发现ARSK在结直肠癌基质细胞中高表达，提示其可能通过调节硫酸肝素降解影响肿瘤侵袭性。
3. **文献名称**: "Structural Mapping of Arylsulfatase K Epitopes via Phage Display-derived Antibodies"
**作者**: Gonzalez R, et al.
**摘要**: 利用噬菌体展示技术筛选ARSK结合抗体，结合X射线晶体学定位抗原表位，为酶活性位点研究提供新工具。
4. **文献名称**: "Development of a High-Sensitivity ELISA Kit for ARSK Quantification in Serum"
**作者**: Wang Y, et al.
**摘要**: 研究团队基于兔多克隆抗体开发ELISA检测法，证实慢性肾病患者血清ARSK水平与硫酸盐代谢紊乱呈正相关。
**提示**：以上为示例性回答，实际文献可能需要通过PubMed或Google Scholar以关键词“Arylsulfatase K antibody”或“ARSK antibody”检索，并关注抗体开发、验证或应用类研究。部分ARSK研究可能涉及基因功能而非抗体工具，需筛选区分。
**Background of ARSK Antibody**
ARSK (Arylsulfatase K) is a member of the sulfatase enzyme family, which catalyzes the hydrolysis of sulfate esters from various substrates, including glycolipids, glycosaminoglycans, and steroids. This enzyme is localized in lysosomes and plays a role in cellular metabolism, particularly in the desulfation of biomolecules, a critical step for their subsequent degradation or functional modification. ARSK shares structural homology with other sulfatases, featuring a conserved active site with a formylglycine residue essential for enzymatic activity.
Biologically, ARSK is implicated in processes such as extracellular matrix remodeling, cellular signaling, and lipid metabolism. Dysregulation of sulfatase activity, including ARSK, has been linked to metabolic disorders, lysosomal storage diseases, and cancer. For example, reduced ARSK expression has been observed in certain cancers, suggesting a potential tumor-suppressive role.
ARSK antibodies are immunological tools designed to detect and quantify ARSK protein levels in research applications. These antibodies enable the study of ARSK’s expression patterns, subcellular localization, and involvement in disease pathways. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Recent studies utilizing ARSK antibodies have explored its interaction with metabolic pathways, its role in tissue homeostasis, and its potential as a biomarker or therapeutic target. The development and validation of high-specificity ARSK antibodies continue to support advances in understanding sulfatase biology and related pathologies.
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