| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | GDE2; PP1665 |
| WB Predicted band size | 69 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human GDPD5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GDPD5抗体的3-4篇虚构示例参考文献(注：实际文献需通过学术数据库查询，以下为模拟内容)：
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1. **文献名称**：*GDPD5 regulates lipid metabolism in cancer cells through phospholipid remodeling*
**作者**：Zhang L, et al.
**摘要**：本研究利用GDPD5特异性抗体，通过免疫印迹和免疫荧光技术，揭示了GDPD5在乳腺癌细胞中通过水解溶血磷脂酸调控膜脂代谢的机制，并发现其表达与患者预后相关。
2. **文献名称**：*Development of a monoclonal antibody against human GDPD5 for neurodegenerative disease studies*
**作者**：Tanaka K, et al.
**摘要**：报道了一种高特异性抗GDPD5单克隆抗体的开发与验证，该抗体成功应用于阿尔茨海默病模型小鼠脑组织中GDPD5蛋白的定位及表达水平检测。
3. **文献名称**：*GDPD5 deficiency alters synaptic plasticity via disrupted glycerophosphocholine homeostasis*
**作者**：Smith J, et al.
**摘要**：通过GDPD5抗体介导的基因敲低实验，发现GDPD5缺失导致神经元突触甘油磷酸胆碱代谢异常，进而影响突触可塑性和认知功能。
4. **文献名称**：*GDPD5 as a biomarker in metabolic syndrome: insights from antibody-based assays*
**作者**：Chen R, et al.
**摘要**：基于GDPD5抗体的ELISA检测方法，发现肥胖患者血清中GDPD5水平升高，提示其可能作为代谢综合征的潜在生物标志物。
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**提示**：实际研究中，建议通过PubMed、Google Scholar等平台以关键词“GDPD5 antibody”、“GDPD5 function”或“Glycerophosphodiesterase PDE5”检索最新文献，重点关注抗体应用(如WB/IHC)或机制研究类论文。
The GDPD5 (Glycerophosphodiester Phosphodiesterase Domain-Containing Protein 5) antibody is a tool used to study the GDPD5 protein, a member of the glycerophosphodiester phosphodiesterase family. This enzyme hydrolyzes glycerophosphodiesters to produce glycerol phosphate and alcohols, potentially influencing lipid metabolism and cellular signaling. GDPD5 is implicated in regulating lysosomal functions, lipid homeostasis, and membrane dynamics, though its precise physiological roles remain under investigation.
Research suggests GDPD5 may interact with pathways involved in neurodegenerative diseases, cancer, and metabolic disorders. For example, altered GDPD5 expression has been observed in certain cancers, hinting at a role in tumor progression or drug resistance. In neuroscience, GDPD5 is linked to lysosomal storage disorders and synaptic function.
GDPD5 antibodies, typically monoclonal or polyclonal, enable detection and localization of the protein in tissues or cell lines via techniques like Western blotting, immunohistochemistry, or immunofluorescence. They are critical for exploring GDPD5’s expression patterns, interactions, and mechanisms in disease models. Validation methods, such as knockout controls or siRNA silencing, ensure antibody specificity. Current studies focus on clarifying GDPD5’s molecular targets and therapeutic potential, positioning it as a biomarker or drug candidate in lipid-related pathologies.
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