| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ARSG |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于 **ARSG抗体**(Arylsulfatase G)的3-4篇参考文献示例(注：根据实际研究领域，ARSG抗体相关文献可能较少，以下为模拟内容)：
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1. **文献名称**: *Arylsulfatase G: Molecular Cloning and Characterization of a Novel Lysosomal Sulfatase*
**作者**: Lüllmann-Rauch R, et al.
**摘要**: 该研究首次克隆并鉴定了ARSG基因，发现其编码一种新型溶酶体硫酸酯酶，参与硫酸酯类化合物的代谢。通过免疫组织化学(使用ARSG特异性抗体)证实其在溶酶体中的定位，并提示其缺陷可能导致溶酶体贮积症。
2. **文献名称**: *Structural Insights into the Substrate Specificity of Arylsulfatase G*
**作者**: Lukatela G, et al.
**摘要**: 通过X射线晶体学解析ARSG的三维结构，结合抗体标记技术分析其底物结合域，揭示了ARSG对特定硫酸酯底物的催化机制，为遗传性代谢疾病的治疗提供潜在靶点。
3. **文献名称**: *ARSG Deficiency in Mice Leads to Neurodegenerative Phenotypes*
**作者**: Zhao H, et al.
**摘要**: 研究利用ARSG基因敲除小鼠模型及抗体免疫检测技术，发现ARSG缺失导致中枢神经系统硫酸酯代谢异常，引发神经元变性，提示ARSG在神经退行性疾病中的潜在作用。
4. **文献名称**: *Development of a High-Affinity Monoclonal Antibody for ARSG Detection in Human Tissues*
**作者**: Smith J, et al.
**摘要**: 报道了一种针对人源ARSG的高特异性单克隆抗体的开发，验证了其在病理组织(如肿瘤和代谢疾病样本)中的检测灵敏度和应用价值，为临床诊断提供新工具。
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**注**：以上文献为示例性内容，实际文献需根据具体数据库(如PubMed、Google Scholar)检索确认。若需真实文献，建议补充关键词或研究背景进一步筛选。
ARGH, or Arylsulfatase G, is a lysosomal enzyme encoded by the *ARSG* gene, belonging to the sulfatase family. It catalyzes the hydrolysis of sulfate esters from glycolipids, glycosaminoglycans, and other substrates, aiding in cellular metabolic recycling. Discovered later than other arylsulfatases (e.g., ARSB, ARSE), ARSG’s biological role remains less characterized. Studies suggest it may contribute to degrading sulfated compounds in lysosomes, with potential links to lysosomal storage disorders (LSDs), though no direct disease association has been conclusively established.
ARSG antibodies are tools used to study the enzyme’s expression, localization, and function. They enable detection via techniques like Western blotting, immunohistochemistry, or immunofluorescence, helping map ARSG distribution in tissues (e.g., liver, kidney) or cellular compartments. Commercial antibodies are typically raised in rabbits or mice against specific peptide epitopes. Research applications include investigating ARSG’s role in sulfatase pathways, substrate specificity, or potential involvement in neurodegenerative or metabolic diseases. However, limited literature and antibody validation pose challenges, necessitating cautious interpretation of results. Ongoing studies aim to clarify ARSG’s physiological and pathological significance, supported by antibody-based assays.
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