Rabbit Polyclonal BCL2L14 Antibody

The BCL2L14 antibody targets the BCL2-like 14 protein (BCL2L14), a member of the BCL-2 family, which regulates apoptosis by modulating mitochondrial outer membrane permeabilization. BCL2L14. also termed BCL-G, is a pro-apoptotic protein containing a conserved BH3 domain critical for its interaction with anti-apoptotic BCL-2 family members. Unlike some BCL-2 proteins, BCL2L14 exhibits tissue-specific expression, with higher levels observed in reproductive tissues, suggesting a role in germ cell apoptosis and developmental processes. Its function remains less characterized compared to other family members like BAX or BCL-2. but studies suggest it may promote apoptosis under stress conditions by counteracting anti-apoptotic signals. Antibodies against BCL2L14 are essential tools for detecting its expression via techniques like Western blotting, immunohistochemistry, or flow cytometry. These reagents help elucidate its localization, expression patterns, and interactions in cellular pathways. Research involving BCL2L14 antibodies has implications for understanding diseases linked to dysregulated apoptosis, including cancer, infertility, and degenerative disorders. However, variability in antibody specificity and cross-reactivity with homologous BCL-2 proteins requires careful validation in experimental settings. Ongoing studies aim to clarify its precise mechanistic role and therapeutic potential as a target for modulating cell survival.