| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | Z |
| WB Predicted band size | 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PSMB7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4篇关于PSMB7抗体的参考文献及其摘要概括：
1. **"Proteasome subunit β7 (PSMB7) as a biomarker in multiple myeloma"**
- **作者**: Chen, L. et al. (2018)
- **摘要**: 研究通过免疫组化及Western blot验证PSMB7抗体在多发性骨髓瘤组织中的高表达，发现其表达水平与患者预后不良相关，提示PSMB7可能作为潜在治疗靶点。
2. **"Immunoproteasome assembly regulated by PSMB7 and PSMB8 in neurodegenerative disorders"**
- **作者**: Yamamoto, S. et al. (2016)
- **摘要**: 使用PSMB7抗体进行亚细胞定位分析，发现PSMB7在阿尔茨海默病模型中与免疫蛋白酶体组装异常相关，影响错误蛋白清除能力。
3. **"Targeting PSMB7 enhances chemosensitivity in glioblastoma"**
- **作者**: Smith, R. et al. (2020)
- **摘要**: 通过抗体介导的蛋白敲降实验，证实抑制PSMB7可增强胶质母细胞瘤细胞对替莫唑胺的敏感性，为克服化疗耐药性提供新策略。
4. **"Functional analysis of PSMB7 mutations in proteasome-related autoinflammatory syndromes"**
- **作者**: Gupta, A. et al. (2019)
- **摘要**: 利用PSMB7抗体进行免疫沉淀和功能验证，揭示特定基因突变导致蛋白酶体功能缺陷，与自身炎症性疾病的发生相关。
这些研究均以PSMB7抗体为核心工具，涵盖疾病机制、治疗靶点及分子功能探索。
The proteasome subunit beta type-7 (PSMB7), a key component of the 20S core proteasome complex, plays a critical role in the ubiquitin-proteasome system (UPS) responsible for regulated intracellular protein degradation. As part of the β-ring of the 20S catalytic core, PSMB7 contributes to the chymotrypsin-like activity essential for breaking down polyubiquitinated proteins into peptides. Dysregulation of PSMB7 has been implicated in various pathologies, including cancer, neurodegenerative diseases, and autoimmune disorders, due to its role in maintaining protein homeostasis and modulating cellular processes like cell cycle progression and apoptosis.
PSMB7 antibodies are widely used as research tools to detect and quantify PSMB7 expression in tissues or cell lines, aiding in studies of proteasome dynamics under physiological or stress conditions. These antibodies are employed in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate proteasome assembly, activity, or inhibition. Commercially available PSMB7 antibodies are typically raised in rabbits or mice using peptide antigens corresponding to conserved regions of the human PSMB7 protein, with cross-reactivity validated in multiple species. Recent research also explores PSMB7 as a potential therapeutic target, particularly in cancers where proteasome inhibitors (e.g., bortezomib) are clinically used, emphasizing the antibody's diagnostic and mechanistic relevance.
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