| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | RS; RGS; ARP1; Brx1; IDG2; IGDS; IHG2; PTX2; RIEG; IGDS2; IRID2; Otlx2; RIEG1 |
| WB Predicted band size | 35 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Fusion protein of human PITX2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于PITX2抗体的3篇示例参考文献(注：文献为示例性虚构，建议通过学术数据库查询真实研究)：
---
1. **文献名称**: *PITX2 as a Biomarker in Atrial Fibrillation: Immunohistochemical Analysis*
**作者**: Smith A, et al.
**摘要**: 本研究通过PITX2抗体对心脏组织样本进行免疫组化染色，发现PITX2在房颤患者右心耳中表达显著下调，提示其可能参与心律失常的分子调控机制。
---
2. **文献名称**: *PITX2 Antibody Validation for Developmental Biology Studies*
**作者**: Lee C, et al.
**摘要**: 该研究验证了PITX2抗体在小鼠胚胎发育中的特异性，证明其在左-右体轴形成过程中调控靶基因表达，为胚胎发育研究提供了可靠工具。
---
3. **文献名称**: *PITX2 Expression in Breast Cancer: Prognostic Implications*
**作者**: Garcia R, et al.
**摘要**: 利用PITX2抗体检测乳腺癌组织微阵列，发现高表达PITX2与患者不良预后相关，表明其可能作为三阴性乳腺癌的潜在治疗靶点。
---
如需具体文献，建议通过PubMed或Google Scholar检索关键词“PITX2 antibody”、“PITX2 immunohistochemistry”获取近期研究。
The PITX2 antibody is a crucial tool in developmental biology and disease research, targeting the Paired-like Homeodomain Transcription Factor 2 (PITX2). PITX2. a member of the bicoid-related homeodomain family, plays a pivotal role in embryonic development, particularly in establishing left-right asymmetry, cardiac morphogenesis, and ocular and craniofacial development. It regulates gene expression by binding to specific DNA sequences, influencing cell differentiation and tissue patterning. Mutations in the PITX2 gene are linked to Axenfeld-Rieger syndrome, characterized by eye abnormalities, dental defects, and cardiac malformations, as well as atrial fibrillation and certain cancers.
Researchers employ PITX2 antibodies to investigate its expression, localization, and functional roles in tissues and disease models. These antibodies are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize PITX2 protein levels in developmental stages or pathological conditions. In cancer studies, PITX2’s dual role as either an oncogene or tumor suppressor, depending on context, makes its antibody valuable for profiling tumor subtypes and understanding metastasis. Additionally, it aids in exploring regenerative mechanisms and developmental pathways in model organisms. Commercial PITX2 antibodies are typically validated for specificity across human, mouse, and rat samples, ensuring broad applicability in translational research.
×
