| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | HIP4 |
| WB Predicted band size | 61 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CBS |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CBS(胱硫醚β-合酶)抗体的参考文献示例(注：文献信息为示例性概括，非真实存在)：
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1. **文献名称**：*Cystathionine Beta-Synthase Expression in Cardiovascular Disease: Role of Antibody-Based Detection*
**作者**：Smith A, et al.
**摘要**：本研究利用特异性CBS抗体，通过免疫组化技术分析动脉粥样硬化患者组织样本，发现CBS表达水平与血管内皮功能损伤呈负相关，提示其在硫化氢代谢中的保护作用。
2. **文献名称**：*Antibody Validation for CBS Localization in Neurological Disorders*
**作者**：Chen L, et al.
**摘要**：通过Western blot和免疫荧光技术验证了CBS抗体的特异性，并发现阿尔茨海默病模型中CBS蛋白在神经元线粒体的异常聚集可能与氧化应激相关。
3. **文献名称**：*CBS Deficiency and Homocystinuria: Diagnostic Applications of Monoclonal Antibodies*
**作者**：Garcia R, et al.
**摘要**：开发了一种高灵敏度CBS单克隆抗体，用于检测基因突变导致的高胱氨酸尿症患者血清及成纤维细胞中CBS蛋白表达缺失，为临床诊断提供工具。
4. **文献名称**：*CBS Antibody-Based Profiling in Cancer Metabolism*
**作者**：Wang Y, et al.
**摘要**：研究利用CBS抗体分析多种癌细胞系，发现CBS在肿瘤细胞中的高表达与硫化氢介导的化疗耐药性相关，提示其作为潜在治疗靶点。
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如需具体文献，建议通过PubMed、Google Scholar等平台检索关键词“CBS antibody”或“cystathionine beta-synthase antibody”获取最新研究。
Cystathionine beta-synthase (CBS) is a key enzyme in the transsulfuration pathway, catalyzing the condensation of homocysteine and serine to form cystathionine, a critical step in cysteine and glutathione biosynthesis. It also participates in hydrogen sulfide (H₂S) production, a gaseous signaling molecule involved in vasodilation, inflammation, and oxidative stress regulation. CBS dysfunction, particularly due to genetic mutations, is linked to homocystinuria, a metabolic disorder characterized by elevated homocysteine levels, leading to ocular, skeletal, and cardiovascular complications.
CBS antibodies are essential tools for studying the enzyme's expression, localization, and activity in both physiological and pathological contexts. They enable researchers to investigate CBS's role in diseases such as cardiovascular disorders, neurodegenerative conditions, and cancer, where altered H₂S metabolism and redox homeostasis are implicated. Commercially available CBS antibodies are typically developed using immunogenic peptides from conserved regions of the enzyme, often validated in applications like Western blotting, immunohistochemistry, and ELISA. Recent studies also explore post-translational modifications (e.g., phosphorylation, S-nitrosylation) regulating CBS activity, further driving demand for specific antibodies. Understanding CBS's dual role in metabolism and signaling continues to be a focus, with antibodies serving as pivotal reagents in unraveling its complex interactions in health and disease.
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