| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human PIM2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PIM2抗体的3篇参考文献示例(注：文献为模拟示例，实际需根据真实研究调整)：
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1. **文献名称**：*PIM2 Kinase Expression in Hematologic Malignancies and Its Inhibition by a Novel Monoclonal Antibody*
**作者**：Smith J. et al.
**摘要**：本研究开发了一种靶向PIM2激酶的单克隆抗体，验证了其在白血病和淋巴瘤细胞系中的特异性结合能力，并证明其通过抑制PIM2活性诱导肿瘤细胞凋亡。
2. **文献名称**：*Role of PIM2 in Solid Tumor Progression: Insights from Antibody-Based Detection*
**作者**：Li Y. et al.
**摘要**：利用PIM2抗体进行免疫组织化学分析，发现PIM2在乳腺癌和前列腺癌中高表达，且其表达水平与患者预后不良相关，提示PIM2可能作为实体瘤治疗的潜在靶点。
3. **文献名称**：*Mechanistic Insights into PIM2 Signaling via Antibody-Mediated Blockade in Multiple Myeloma*
**作者**：Garcia R. et al.
**摘要**：通过PIM2功能阻断性抗体，揭示PIM2在多发性骨髓瘤细胞中的促生存信号通路机制，证实抗体干预可有效抑制肿瘤生长并增强化疗敏感性。
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如需准确文献，建议通过PubMed或Google Scholar检索关键词“PIM2 antibody”或“PIM2 kinase therapeutic targeting”获取最新研究。
PIM2 antibodies are immunological tools designed to target the Proviral Integration site for Moloney murine leukemia virus 2 (PIM2) kinase, a serine/threonine kinase involved in cell survival, proliferation, and apoptosis regulation. The PIM2 gene, part of the PIM kinase family (PIM1. PIM2. PIM3), is frequently overexpressed in hematological malignancies (e.g., leukemia, lymphoma) and solid tumors, where it promotes oncogenesis by phosphorylating substrates like BAD, c-MYC, and 4E-BP1. thereby enhancing cell cycle progression and inhibiting apoptosis.
PIM2 antibodies are widely used in research to detect PIM2 protein expression levels, study its role in cancer signaling pathways, and evaluate its potential as a therapeutic target. They are essential in techniques such as Western blotting, immunohistochemistry (IHC), and flow cytometry. Due to structural similarities among PIM kinases, high-specificity PIM2 antibodies are critical to avoid cross-reactivity with PIM1 or PIM3. Many commercially available antibodies are validated using knockout cell lines or siRNA-mediated silencing to confirm target specificity.
In therapeutic contexts, PIM2 inhibitors are under investigation, and corresponding antibodies aid in pharmacodynamic studies by monitoring kinase inhibition. Overall, PIM2 antibodies serve as vital reagents for both basic research and translational studies in oncology and immunology.
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