| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ZFYVE11; FYVE-DSP2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human MTMR4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是几篇关于MTMR4抗体的模拟参考文献(请注意，以下内容为示例，实际文献需通过学术数据库查询)：
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1. **文献名称**: *MTMR4 regulates autophagy in cancer cells through PI3K/Akt/mTOR signaling*
**作者**: Smith A, et al.
**摘要**: 本研究利用MTMR4特异性抗体，通过Western blot和免疫荧光技术，发现MTMR4在乳腺癌细胞中表达下调，并通过调控PI3K/Akt/mTOR通路抑制自噬，提示其可能作为癌症治疗的潜在靶点。
2. **文献名称**: *The role of MTMR4 in TGF-β receptor trafficking and signaling*
**作者**: Zhang L, et al.
**摘要**: 作者使用MTMR4抗体进行免疫共沉淀和免疫组化实验，证明MTMR4通过与TGF-β受体II结合，调控其内吞和溶酶体降解，从而影响细胞对TGF-β信号的响应。
3. **文献名称**: *MTMR4 deficiency leads to cardiac dysfunction in mice*
**作者**: Lee J, et al.
**摘要**: 通过MTMR4抗体检测基因敲除小鼠的心脏组织，发现MTMR4缺失导致心肌细胞中磷脂代谢异常，引发线粒体功能障碍和心力衰竭，表明其在心脏生理中的关键作用。
4. **文献名称**: *Antibody-based profiling of MTMR family proteins in human diseases*
**作者**: Brown K, et al.
**摘要**: 这篇综述总结了MTMR家族蛋白(包括MTMR4)的抗体开发进展，强调其在神经退行性疾病和癌症中的异常表达模式，并讨论了相关抗体在诊断中的应用潜力。
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**备注**：以上内容为基于MTMR4已知功能的模拟摘要，实际文献请通过PubMed、Google Scholar等平台以关键词“MTMR4 antibody”或“Myotubularin-related protein 4”检索。如需具体文献指导，可提供更详细的研究背景需求。
The MTMR4 (Myotubularin-Related Protein 4) antibody is a tool used to study the MTMR4 protein, a member of the myotubularin family of lipid phosphatases. MTMR4 specifically dephosphorylates phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 3.5-bisphosphate [PI(3.5)P2], phosphoinositide lipids that regulate membrane trafficking, autophagy, and cellular signaling. Unlike other myotubularin-related proteins, MTMR4 lacks a functional phosphatase domain and instead forms heterodimers with catalytically active family members (e.g., MTMR1/2) to modulate their enzymatic activity or substrate specificity.
MTMR4 is implicated in diverse cellular processes, including endosomal sorting, receptor degradation, and cytoskeletal organization. Dysregulation of MTMR4 has been linked to cancer progression, neurodevelopmental disorders, and muscular pathologies, though its exact role remains under investigation. The MTMR4 antibody enables researchers to detect and quantify MTMR4 expression in tissues or cell lines via techniques like Western blotting, immunofluorescence, or immunohistochemistry. It is also used to explore MTMR4’s interactions with signaling partners and its subcellular localization, particularly in endosomal compartments.
Current research focuses on clarifying MTMR4’s regulatory mechanisms in phosphoinositide metabolism and its potential as a therapeutic target. The antibody’s specificity and reliability are critical for dissecting MTMR4’s contributions to disease pathways and cellular homeostasis.
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