Rabbit Polyclonal ASB10 Antibody

The ASB10 antibody targets the Ankyrin Repeat and SOCS Box Protein 10 (ASB10), a member of the ASB family involved in ubiquitin-mediated protein degradation. ASB proteins typically function as substrate-recognition components of E3 ubiquitin ligase complexes, facilitating the tagging of specific proteins for proteasomal degradation. ASB10 contains ankyrin repeat domains, which mediate protein-protein interactions, and a C-terminal SOCS box that binds E3 ligase machinery. While the biological roles of ASB10 remain under investigation, studies suggest its involvement in ocular physiology, particularly in regulating intraocular pressure. Research links ASB10 expression to the ciliary epithelium of the eye, where it may influence aqueous humor dynamics, potentially impacting glaucoma pathogenesis. Mutations in the ASB10 gene have been associated with primary open-angle glaucoma in some populations, highlighting its clinical relevance. ASB10 antibodies are primarily utilized in biomedical research to detect protein expression, localization, and interaction partners via techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation. These tools aid in elucidating ASB10's molecular mechanisms, including its potential substrates and regulatory pathways. However, the functional characterization of ASB10 remains incomplete, necessitating further studies to define its precise physiological and pathological roles.