Rabbit Polyclonal SEPTIN7 Antibody

SEPTIN7 is a member of the septin family of GTP-binding proteins, which are conserved cytoskeletal components involved in diverse cellular processes, including cell division, membrane remodeling, vesicle trafficking, and apoptosis. SEPTIN7 forms hetero-oligomeric complexes with other septins (e.g., SEPTIN2. SEPTIN6. SEPTIN9) to assemble into higher-order structures such as filaments, rings, or barriers that regulate cell polarity and compartmentalization. The SEPTIN7 antibody is a crucial tool for detecting and studying the expression, localization, and function of the SEPTIN7 protein in various biological contexts. It is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate its role in physiological processes (e.g., neuronal development, ciliogenesis) and diseases. Dysregulation of SEPTIN7 has been linked to pathologies such as neurodegenerative disorders (e.g., Alzheimer’s disease, Parkinson’s disease) and cancers, where altered expression correlates with tumor progression, metastasis, or chemoresistance. Studies also suggest SEPTIN7 involvement in microbial infection responses and immune regulation. Researchers rely on validated SEPTIN7 antibodies to explore its interactions within septin complexes, its post-translational modifications, and its potential as a diagnostic or therapeutic target. Commercial antibodies are typically raised against specific epitopes, with validation in knockdown models ensuring specificity for accurate experimental outcomes.