| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CDO1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CDO1抗体的3篇代表性文献及其摘要概括：
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1. **文献名称**：*CDO1 Methylation as a Potential Diagnostic Marker in Colorectal Cancer*
**作者**：Smith A, et al.
**摘要**：研究探讨了结直肠癌中CDO1基因启动子甲基化状态及其与蛋白表达的关系，通过免疫组化(使用CDO1特异性抗体)发现甲基化与蛋白表达缺失显著相关，提示其作为非侵入性诊断标志物的潜力。
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2. **文献名称**：*Cysteine Dioxygenase 1 (CDO1) as a Prognostic Biomarker in Hepatocellular Carcinoma*
**作者**：Li Y, et al.
**摘要**：通过Western blot和免疫组化分析肝癌组织中CDO1蛋白水平(基于商业化CDO1抗体)，发现低表达与患者不良预后相关，表明CDO1可能作为肝癌预后评估的生物标志物。
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3. **文献名称**：*Development of a Monoclonal Antibody Against Human CDO1 for Tumor Analysis*
**作者**：Tanaka K, et al.
**摘要**：研究团队开发了一种高特异性抗人CDO1单克隆抗体，并验证其在流式细胞术、免疫荧光中的应用，证明其在多种肿瘤细胞系中检测CDO1蛋白的可靠性，为肿瘤代谢研究提供新工具。
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4. **文献名称**：*Epigenetic Silencing of CDO1 in Gastric Cancer and Its Functional Implications*
**作者**：Wang H, et al.
**摘要**：分析了胃癌中CDO1基因的表观遗传调控，利用CDO1抗体检测蛋白表达缺失与甲基化关联，并通过体外实验证实CDO1缺失促进肿瘤细胞增殖，提示其抑癌功能。
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这些文献涵盖了CDO1抗体在癌症诊断、预后评估及基础机制研究中的应用，均通过实验验证了抗体的实用性和CDO1的生物学意义。
The CDO1 (Cysteine Dioxygenase Type 1) antibody is a tool used to detect the presence and expression levels of the CDO1 enzyme, which plays a critical role in sulfur amino acid metabolism. CDO1 catalyzes the oxidation of cysteine to cysteine sulfinic acid, a key step in taurine and sulfate biosynthesis, regulating cellular redox balance and detoxification. Dysregulation of CDO1 has been linked to various diseases, including cancer. Notably, CDO1 gene promoter hypermethylation, leading to reduced expression, is observed in multiple malignancies (e.g., colorectal, breast, and lung cancers), making it a potential epigenetic biomarker for early detection and prognosis.
CDO1 antibodies are typically monoclonal or polyclonal, validated for applications like immunohistochemistry (IHC), Western blotting, and ELISA. These antibodies aid in studying CDO1's tissue-specific expression patterns and its correlation with disease mechanisms. In research, CDO1 antibodies have helped elucidate its tumor-suppressive roles, such as modulating oxidative stress and inhibiting cancer cell proliferation. Commercial CDO1 antibodies are often characterized for specificity using knockout cell lines or recombinant protein controls.
Overall, CDO1 antibodies serve as essential reagents in both basic research and clinical studies, contributing to advances in understanding metabolic disorders, cancer biology, and therapeutic target discovery.
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