Rabbit Polyclonal CHMP1A Antibody

The CHMP1A antibody is a research tool designed to detect Charged Multivesicular Body Protein 1A (CHMP1A), a key component of the Endosomal Sorting Complex Required for Transport (ESCRT) machinery. CHMP1A plays a critical role in membrane remodeling processes, including multivesicular body (MVB) formation, cytokinesis, viral budding, and plasma membrane repair. As part of the ESCRT-III subcomplex, it facilitates the sorting of ubiquitinated cargo into intraluminal vesicles and mediates membrane scission events. The CHMP1A antibody is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study the protein’s expression, localization, and interactions in cellular pathways. Dysregulation of CHMP1A has been linked to neurodegenerative disorders, cancer, and developmental defects, particularly microcephaly and spinal muscular atrophy, due to its role in neural development and cell cycle regulation. Researchers utilize this antibody to explore CHMP1A’s involvement in disease mechanisms, ESCRT-dependent processes, and its potential as a therapeutic target. Validation of antibody specificity, often through knockout controls, is essential to ensure accurate detection given the structural homology among ESCRT-III family members.